右美托咪定对小儿七氟烷mac_ti的影响

《右美托咪定对小儿七氟烷mac_ti的影响》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、复旦大学硕士研宄生学位论文随右美托咪定剂量的增加而降低，两者呈二次相关。4、右美托咪定静脉输注未使患儿的心率、血压、氧饱和度、呼吸频率和呼气末二氧化碳产生巨大波动，无不良事件发生。结论：右美托咪定用于小儿麻醉诱导是安全且有效的。随着右美托咪定输注剂量的增加，七氟烷MACTi逐渐降低。l.Oug/kg(0.5ug/kg/h维持）右美托咪定可使七氟烷MACti降低34%;2.0ug/kg(1.0ug/kg/h维持）右美托咪定可使七氟烷MACTI降低61%o关键词：右美托咪定，七氟烷，小儿，气管插管，最低肺泡有效浓度2复旦人?学硕上研究生学位论文Effe

2、ctsofDexmedetomidineonminimumalveolarconcentrationofsevofluranerequiredfortrachealintubationinchildrenwithoutneuromuscularblockAbstractObjective.Weinvestigatedtheeffectsofdifferentdosesofdexmedetomidineinfusionontheminimumalveolarconcentrationofsevofluranerequiredfortrachealin

3、tubation(MACTi)inchildrenwithouttheuseofneuromuscularblockingdrugs.Methods.Inaprospective,double-blindedparallel,randomizedmanner,67children(ASAIorII,age3-8yr)undergoingselectivesurgerywereallocatedtooneofthreegroups:salineonly(groupD0),abolusdoseofl.Oug/kgdexmedetomidinefollo

4、wedbyacontinuousinfusionof0.5ug/kg/h(groupDi),orabolusdoseof2.0ug/kgdexmedetomidinefollowedbyacontinuousinfusionofl.Oug/kg/h(groupD2).ThebolusdoseofdexmedetomidinewasinfusedforlOminandthenanaesthesiawasinducedwith5%sevoflurane.Afterthetargetconcentrationofsevofluranewasmaintai

5、nedstablefor15min,laryngoscopyandtrachealintubationwerequicklyattempted.Successfulintubationwasdefinedasexcellentintubatingconditions.Predeterminedend-tidalsevofluraneconcentrationsforeachgroupweredeterminedusingtheDixonup-and-downmethod.Theinitialconcentrationofsevofluranewer

6、e3.50%,2.50%and1.50%ingroupD0/groupDiandgroupD2andstepwere0.3%,0.2%and0.1%ineachgroup.Childrenwereincludeduntilsevenindependentpairs(i.e.notexcellenttoexcellentintubation)ofconsecutivesubjectswereobtainedineachgroup.MACnwasdeterminedineachgroupbycalculatingthemeanofthemidpoint

7、concentrationofallindependentpairsofpatientswhomanifestedacrossoverfromanegativeresponsetoapositiveone.Results.Nodifferencesinage,weight,gender,ASAphysicalstatus,3复p.人学硕上研宄生学位论文dexmedetomidineinfusiontime,ortrachealintubationtimewerereportedamongthethreegroups.TheMACT!ofsevofl

8、uranewererespectively3.61(3.42?3.80)%ingroupD0,2.40(2.25?2.55