冠心病患者血清CyPA水平变化及临床意义.pdf

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1、3278重庆医学2014年9月第43卷第25期论著·临床研究doi：10．3969／j．issn．1671—8348．2014．25．005冠心病患者血清CyPA水平变化及临床意义宣玲一，吴继雄，唐碧，蔡鑫(1．安徽医科大学第二附属医院心血管内科，合肥230601；2．蚌埠医学院第一附属医院心血管内科，安徽蚌埠230004)摘要：目的观察冠心病患者血清亲环素A(CyPA)水平变化，探讨其临床意义。方法64例确诊冠心病的患者(冠心病组)，依临床类型分为稳定型心绞痛组(SAP组)、不稳定型心绞痛组(UAP组)、急性心肌梗死组(AMI组)；依冠状动脉病变范围分为单支组、双支组、多支组；

2、26例检查正常者为对照组。采用ELISA法测CyPA和基质金属蛋白酶9(MMP一9)水平，免疫散射比浊法测C一反应蛋白(CRP)水平。结果冠心病组CyPA、MMP一9、CRP明显高于对照组(P0．05)；单支组、双支组、多支组CyPA、MMP-9、CRP显著高于对照组(P

3、9，P

4、iMedicalUniversity，Hefei，Anhui230601，China；2．DepartmentofCardiology，FirstAffiliatedHospitalofBengbuMedicalCollege，Bengbu，Anhui233004，China)Abstract：ObjectiveToobservetheserumcyclophilinA(CyPA)levelchangeinthepatientswithcoronaryheartdisease(CHD)andtoinvestigateitsclinicalsignificance．Methods6

5、4patientswithCHD(CHDgroup)weredividedintothreegroupsac—cordingtotheclinicaltypes：stableanginapectoris(SAP)group，unstableanginapectoris(UAP)groupandacutemyocardialinfarc—tion(AMI)group；whichweredividedintothreegroupsaccordingtothecoronaryarterylesionrange：singlevessellesiongroup，doublevesselsl

6、esionsgroupandmultivesselslesionsgroup；while26controlswithnormalcoronaryarterieswereselectasthecon—trolgroup．SerumlevelsofCyPAandmatrixmetanoproteinase_9(MMP一9)weredetectedbyELISA，andC—reactiveprotein(CRP)concentrationwasdetectedbytheimmunescatteringturbidimetrytest．ResultsTheCyPA，MMP-9andCRP

7、levelsintheCHDgroupweresignificantlyhigherthanthoseinthecontrolgroup(P<0．01)；theCyPAandCRPlevelsintheAMIgroupandtheUAPgroupweresignificantlyhigherthanthoseinthecontrolgroupandtheSAPgroup(P％0．05)，theCyPAandCRPlevelshadnostatisticallysignifican