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时间:2020-05-02
《PCT、IL-6及CRP在伴外科并发症的过敏性紫癜患儿血清中变化的意义.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·660·临床儿科杂志第32卷第7期2014年7月JClinPediatrVoL32No.7JuL2014doi:10.3969/j.issn.1000-3606.2014.07.016·论著·PCT,IL-6及CRP在伴外科并发症的过敏性紫癜患儿血清中变化的意义李斌德颜禄斌达怡辰沈阳李刚李来元兰州大学第二医院小儿外科(甘肃兰州730030)摘要:目的探讨伴腹部外科并发症的过敏性紫癜(HSP)患儿血清前降钙素(PCT)、白介素一6(IL·6)及C一反应蛋白(CRP)水平的动态变化。方法选择2010年1月至2013年6月期间住院的伴腹部外科并发症的HSP患儿48例,于人院第1、3
2、、5天及出院前采集空腹静脉血,检测血清PCT、IL一6及CRP水平。结果HSP患儿入院第1、3、5天血清PCT、IL-6水平以及人院第1、3天血清CRP水平均高于对照组,差异有统计学意义(P均<0.05)。手术组和非手术组HSP患儿,人院第1、3、5天以及出院前血清PCT、CRP和IL.6水平的差异有统计学意义(尸均<0.01),均呈逐渐下降趋势。手术治疗患儿第3、5天的血清PCT、IL-6水平低于非手术治疗患儿,第5天血清CRP水平低于非手术治疗患儿,差异有统计学意义均3、。结论PCT、IL-6及CRP水平变化可能与HSP伴发的腹部外科并发症的发生与感染因素关系密切,监测其变化有助于判断病情及指导治疗。关键词:前降钙素;白介素.6;C反应蛋白;过敏性紫癜;儿童Thechangesofserumprocalcitonin,interleukin一6andCreactiveproteininchildrenwithHenoch-SchSnleinpurpuracombinedwithsurgicalcomplicationsL1Binde,】ⅣLubin,DAYichen,SHENYang,LIGang,L1Laiyuan(DepartmentofP4、ediatricSurgery,TheSecondHospitalofLanzhouUniversity,Lanzhou730030,Gansu,China)Abstract:ObjectiveToinvestigatethechangesofserumprocalcitonin(PCT),interleukin-6(IL-6)andCreactiveprotein(CRP)inchildrenwithHenoch-Sch6nleinpurpura(HSP)combinedwithsurgicalcomplications.MethodsFromJanuary2010toJun5、e2013,48childrenwithHSPcombinedsurgicalcomplicationswereenrolled,thefastingvenousbloodwereobtainedinday1,3,5ofadmissionandbeforedischarge.Meanwhile,30healthychildrenwereselectedascontro1.ResultsComparedwiththecontrolgroup,thelevelsofserumPCTandIL一6inday1,3,5ofadmission,andthelevelsofserumCRP6、inday1,3ofadmissionwerehigherinchildrenwithHSPcombinedwithsurgicalcomplications(allP<0.01).ThedifferencesoflevelsofserumPCT,CRPandIL一6inday1,3,5ofadmissionandbeforedischargewerestatisticallysignificantbetweensurgicalgroupandnon-surgicalgroup.Alltheseindicatorsshowedagradualdownwardtrend.Comp7、aredwithsurgicalgroup,thelevelsofserumPCTandIL-6inday3,5ofadmissionandserumCRPinday5ofadmissionweresignificantlylowerinnon-surgicalgroup
3、。结论PCT、IL-6及CRP水平变化可能与HSP伴发的腹部外科并发症的发生与感染因素关系密切,监测其变化有助于判断病情及指导治疗。关键词:前降钙素;白介素.6;C反应蛋白;过敏性紫癜;儿童Thechangesofserumprocalcitonin,interleukin一6andCreactiveproteininchildrenwithHenoch-SchSnleinpurpuracombinedwithsurgicalcomplicationsL1Binde,】ⅣLubin,DAYichen,SHENYang,LIGang,L1Laiyuan(DepartmentofP
4、ediatricSurgery,TheSecondHospitalofLanzhouUniversity,Lanzhou730030,Gansu,China)Abstract:ObjectiveToinvestigatethechangesofserumprocalcitonin(PCT),interleukin-6(IL-6)andCreactiveprotein(CRP)inchildrenwithHenoch-Sch6nleinpurpura(HSP)combinedwithsurgicalcomplications.MethodsFromJanuary2010toJun
5、e2013,48childrenwithHSPcombinedsurgicalcomplicationswereenrolled,thefastingvenousbloodwereobtainedinday1,3,5ofadmissionandbeforedischarge.Meanwhile,30healthychildrenwereselectedascontro1.ResultsComparedwiththecontrolgroup,thelevelsofserumPCTandIL一6inday1,3,5ofadmission,andthelevelsofserumCRP
6、inday1,3ofadmissionwerehigherinchildrenwithHSPcombinedwithsurgicalcomplications(allP<0.01).ThedifferencesoflevelsofserumPCT,CRPandIL一6inday1,3,5ofadmissionandbeforedischargewerestatisticallysignificantbetweensurgicalgroupandnon-surgicalgroup.Alltheseindicatorsshowedagradualdownwardtrend.Comp
7、aredwithsurgicalgroup,thelevelsofserumPCTandIL-6inday3,5ofadmissionandserumCRPinday5ofadmissionweresignificantlylowerinnon-surgicalgroup
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