子痫前期患者血清25-羟维生素D水平检测的临床意义-论文.pdf

《子痫前期患者血清25-羟维生素D水平检测的临床意义-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、·3318·国际检验医学杂志2013年12月第34卷第24期hltJLabMed，December2013，Vot．34，No．24·临床检验研究论著·子痫前期患者血清25一羟维生素D水平检测的临床意义罗颖贞，侯延庆△，尹昕(广东医学院附属南山医院，广东深圳518052)摘要：目的探讨予痫前期患者血清25一羟维生素D[25-(OH)D]水平检测的临床意义。方法采用ELISA法及离子选择电极法测定200例妊娠期高血压疾病(妊娠高血压41例、子痫前期轻度3O例、子痫前期重度131例)及300例正常晚期妊娠妇女血清25一(OH)D及钙的水平。结果正常晚期妊娠组血清钙水平(2．46士0．11)

2、retool／L，25一(OH)D水平(51．37±13．19)nmol／L，均明显高于妊娠期高血压疾病组(P

3、5一(OH)D水平(27．12±9．1)nmol／L，均明显高于早发型(PO．05)。结论低水平血清25一(OH)D可能与子痫前期的发生、发展有关。关键词：血清钙；25一羟维生素D；子痫前期DOI：10．3969／j．issn．1673—4130．2013．24．022文献标识码：A文章编号：1673-4130(2013)24—3318-02Clinicalsignificanceof

4、serum25。hydroxyvitaminDlevelsinpreeclampsiapatientsLuoYingzhen。HouYanqing△。YinXin(NanshanHospitalAffiliatedtoGuangdongMedicalCollege，Shenzhen，Guangdong510852，China)Abstract：ObjectiveTostudytheclinicalsignificanceofserum25一hydroxyvitaminD[25一(0H)D]levelsinpreeclampsiapait—ents．Methods200womenwith

5、hypertensivedisordercomplicatingpregnancy(HDCP)wereenrolledinthestudy，including41womenwithpregnancyhypertension，30womenwithmildpreeclampsiaand131womenwithseverepreeclampsia．72norma1latepregnant(NLP)womenwereinvolved．The1evelsofserumcalciumweremeasuredbyionselectiveelectrodemethod．andthelevelsofs

6、erum25一(OH)DweremeasuredbvELISA．ResultsThe1evelsofserumcalciumand25一(0H)DweresignificantlyhigherinNLPwomenthaninwomenwithHDCP，P<0．05．Thelevelsofserumcalciumand25一(OH)Dweresignificantlyhigherinwomenwithmildpreeclampsia(roPE)thaninwomenwithseverepreeclampsia(sPE)，P<0．05．Thelevelsofserumcalciumand2

7、5一(OH)Dweresignificantlyhigherinlateonsetseverepreeclampsia(LOSP)thaninwomenwithearlyonsetseverepreeclampsia(EOSP)，P<0．05．TherewasnodifferencebetweenwomenwithHDCPandwomenwithmPE(P>0．05)．ConclusionThe1owerlevelsofserumvitamin