鸦胆子油乳联合顺铂腹腔灌注治疗卵巢癌的效果.doc

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1、鸦胆子油乳联合顺钳腹腔灌注治疗卵巢癌的效果［摘要］目的探讨鸦胆子油乳联合顺钳腹腔灌注治疗卵巢癌的效果。方法选取2014年1月〜2015年2月在本院就诊的卵巢癌患者127例，将其根据治疗方法分为治疗组5二74)和对照组(n二53)。对照组给予单纯顺钳腹腔灌注治疗，治疗组在对照组基础上给予联合鸦胆子油乳进行局部化疗，化疗3周后，评估两组的腹水疗效、临床症状总改善率、生活质量提高率和毒副反应发生情况。结果腹水疗效的比较：治疗组的有效率为83.8%,明显高于对照组的62.3%(P<0.05)；治疗组的临床症状总改善率为90.5%,明显高于对照组的69.8%,患者生活质量评分

2、提高率为78.4%,明显高于对照组的62.3%(P<0.05)；治疗组的白细胞下降发生率为54.1%,对照组为71.7%,两组差异有统计学意义(P〈0・05)。结论鸦胆子油乳联合顺钳腹腔灌注化疗是一种安全、有效的卵巢癌治疗方法。［关键词］鸦胆子油乳；顺钳；卵巢癌；腹腔灌注［中图分类号］R737.31［文献标识码］A［文章编号］1674-4721(2015)07(b)-0115-03［Abstract］ObjectiveTostudytheeffectofbruceolicoilemulsioncombinedwithcisplatinforperitonealper

3、fusiontreatingovariancancer・MethodsFromJanuary2014toFebruary2015,127patientswithovariancancertreatedinourhospitalwereselectedandtheyweredividedintotreatmentgroup(n=74)andcontrolgroup(n=53)accordingtothetreatmentmethod.Controlgroupwastreatedwithsimplecisplatinforperitonealperfusion,whil

4、etreatmentgroupwastreatedwithbruceolicoilemulsionforlocalchemotherapyonthebasisofcontrolgroup.Thecurativeeffectofascites,thetotalimprovementrateofclinicalsymptom,theimprovementrateoflifequalityandtheincideneeoftoxicsidereactionintwogroupswereevaluated・ResultsThecomparisionofcurativeeff

5、ectofascites：theeffectiverateoftreatmentgroup(83.8%)wasobviouslyhigherthanthatofcontrolgroup(62.3%)(P<0.05)；thetotalimprovementrateofclinicalsymptomoftreatment,group(90.5%)wasobviouslyhigherthanthatofcontrolgroup(69.8%),theimproveiiientrateoflifequalitytreatmentgroup(78・4%)wasobviously

6、higherthanthatofcontrolgroup(62.3%)(P〈0.05)；therateofwhitecel1decreasingintreatmentgroupwas54.1%,whileitwas71.7%incontrolgroup,andtherewasastatisticaldifferencebetweentwogroups(P<0.05)•ConclusionBruceolicoilemulsioncombinedwithcisplatinforperitonealperfusionisasafeandeffectivemethodfor

7、treatmentofovariancancer.[Keywords]Bruceolicoi1emulsion；Cisplatin；Ova/ri且ncancer；Peritonealperfusion卵巢癌是妇科常见的恶性肿瘤，其恶性程度高，极易转移，预后差，60%〜70%的卵巢癌患者诊断时已处于晚期[1-2]o晚期卵巢癌常合并大量腹水，出现腹胀、纳差、乏力等临床症状，营养物质如蛋白质、电解质因反复引流腹水而大量丢失，因而患者体质均较差，不能耐受手术治疗［3］。有效控制腹水，提高卵巢癌患者的生活质量后再行肿瘤细胞减灭术，往往能提高患者对手术的耐受性，从而达到满意