托烷司琼联合地塞米松预防顺铂化疗所致恶心呕吐的临床研究.pdf

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1、安徽医学第35卷第3期282AnhuiMedicalJourna12014年3月托烷司琼联合地塞米松预防顺铂化疗所致恶心呕吐的临床研究孙媛媛谢军鲍健彭丽娟[摘要]目的观察托烷司琼联合地塞米松预防顺铂方案化疗所导致的恶心、呕吐，评价其安全性。方法将50例含顺铂20mg／(m·d)×5d化疗方案的恶性肿瘤患者随机分为两组，观察组26例接受托烷司琼联合地塞米松治疗，对照组24例接受托烷司琼治疗。观察患者化疗引起的急性期、延迟期呕吐的完全缓解率及无呕吐发作率。结果观察组急性期、延迟期呕吐完全缓解率优于对照组，差异有统计学意义(P<0．05)。观察组急性期、延迟期无呕吐发作率优于对照组，差异有

2、统计学意义(P<0．05)。两组患者不良反应主要为头痛、便秘、腹部不适，症状轻微，患者耐受。结论托烷司琼联合地塞米松能有效预防顺铂化疗所致的急性期、延迟期呕吐反应，且安全性较好。[关键词]地塞米松；托烷司琼；化疗；恶心；呕吐doi：10．3969／j．issn．1000—0399．2014．03．005ClinicalobservationoftropisetroncombinedwithdexamethasonepreventingnauseaandvomitinginducedbychemotherapywithcisplatinSunYuanyuan，XieJun，BaoJia

3、n，etalDepartmentofMedicalOncology，theThirdHospitalofAnhtdMedicalUniversity，Hefei230001，China[Abstract]0bjectiveToobservetheeffectoftropisetroncombinedwithdexamethasoneonpreventingnauseaandvomitinginducedbychemotherapywitheisplatin．MethodsFiftypatientswithcancerundergoingchemotherapyregimensincl

4、udingcisplatinDDP20mg／(m·d)×5dweredividedrandomlyintoexperimentalgroupwith26patientsandcontrolgroupwith24patients．Thepatientsintheexperimentalgroupweregiventropisetroncombinedwithdexamethasone，andthepatientsinthecontrolgroupweregiventropisetron．Thesituationofnan—sea，vomitingandadversereactionsw

5、asobservedandrecorded．ResultsTheincidentratesofbothnauseaandvomitingintheexperimentalgroupweresignificantlydepressedcomparedwiththoseinthecontrolgroup(P<0．05)．TherewassignificantdifferenceinCRRduringacutephaseanddelayedphasebetweentreatmentgroupandcontrolgroup(P<0．05)．Therewassignificantdiffere

6、nceinpercentageofnovomitingattackduringacutephaseanddelayedphase(P<0．05)．Theadversereactionsweremildandgenerallywelltoleratedinpatientsoftwogroups．ConclusionTropisetroncombinedwithdexamethasoneissafeandeffectiveinpreventingnauseaandvomitinginducedbychemo—therapywitheisplatin．[Keywords]Dexametha

7、sone；Tropisetron；Chemotherapy；Nausea；Vomiting化疗是治疗恶性肿瘤重要的手段之一，顺铂是重要Hydroxytryptamine3，5-HT3)受体拮抗剂的应用，化疗导的化疗药物之一，其抗癌谱广，抗癌活性高，交叉耐药性致的恶心、呕吐等胃肠道反应较前明显减低引。低，有利于临床联合用药，但顺铂引起恶心、呕吐的发生托烷司琼是神经系统高效5-HT3受体拮抗剂之率几乎为100％。随着5羟色胺3(5一一，与地塞米松联合可增强5一