铜绿假单胞菌注射液联合顺铂治疗消化道恶性腹腔积液的临床研究.pdf

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1、．7120．现代生物医学进展www~hengwuyixue．tomProgressinModernBiomedicineVoL13NO．36DEC．2013铜绿假单胞菌注射液联合顺铂治疗消化道恶性腹腔积液的临床研究术魏孝礼白玉贤△李燕京张婷婷孙丽立(哈尔滨医科大学附属肿瘤医院肿瘤内科黑龙江哈尔滨15008I)摘要目的：比较铜绿假单胞菌注射液联合顺铂与单纯使用顺铂治疗消化道恶性腹腔积液的疗效。方法：将250例消化道恶性中等量以上腹腔积液患者分为对照组和实验组各125例。所有患者行穿刺置管引流术，地塞米松预防发热，予盐酸利多卡因预防腹痛。铜绿假单胞菌注射液每周两次，顺铂每周一次，疗程一周

2、，最多两个疗程。结果：实验组患者有效率为85．6％，其中，完全缓解40例，部分缓解67例。对照组例患者有效率为52％，其中，完全缓解24例，部分缓解4l例。两组比较差异有统计学意义(xZ=-32．87，P<0．05)。实验组患者WHO体力状态评分(1分和2分)为104例，有效率为83．2％；对照组患者WHO体力状态评分(1分和2分)为72例，有效率为57．6％。两组比较差异有统计学意义(x~19．67，P<0．05)。结论：铜绿假单胞茵注射液联合顺铂腹腔内给药治疗消化道恶性腹腔积液。临床疗效显著。关键词：铜绿假单胞菌注射液；顺铂；恶性腹腔积液中图分类号：R735文献标识码：A文章编号

3、：1673—6273(2013)36—7120—04ClinicalStudvofPseudomonasAeruginosaCombinedwithCisplatininPatientswithMalignantAscites*WEIXiao-li,BAIYu-xiatr~,LIYan-jing,ZHANGTing-ting,SUNLi-lifTheThirdAffiliatedHospitalofHarbinMedicalUniversity,Harbin,Heilongfiang,150081，Provinc~China)ABSTRACTObjective：Toevaluatet

4、heclinicaleficacyofpseudomonascombinedwithcisplatinonthetreatmentofthemalignantascites．Methods：250patientswithmoderateormoremalignantasciteswereincludedinthisstudyanddividedintotheexperimentalgroupandthecontrolgroup．Thepatientsintheexperimentalgroupweregiventhepseudomonasaeruginosacombinedwitht

5、hecis—platin，whilethepatientsinthecontrolgroupweregivencisplatin．Aftertheabdominalparacentesisandcatheterizationwereperformed，thepatientsweregivendrug．Dexamethasonewasusedtopreventfeverandlidocainehydrochloridetopreventabdominalpain．Pseu—domonasaeruginosawasinjected2timesperweekandcisplatin1tim

6、eperweekuntiloneweek．Results：Theefectiverateintheexperi—mentalgroupwas85．6％．whichincluding40casesincompleteremissionand67casesinpartialremission．Theeffectiverateinthecon—trolgroupwas52％including24casesincompleteremissionand41casesinpartialremissionwithstatisticallysignificantdiferences(x32．87，P

7、<0．05)．AccordingtotheWHOperformancestatusscore，theefectiverateinexperimentalgroupwas83．2％(104cases)，and57．6％inthecontrolgroup(72cases)．Therewerestatisticallysignificantdiferencesbetweentwogroups(x2=-19．67．P