铜绿假单胞菌注射液联合多西他赛和顺铂治疗肺癌所致恶性胸腔积液疗效观察-论文.pdf

《铜绿假单胞菌注射液联合多西他赛和顺铂治疗肺癌所致恶性胸腔积液疗效观察-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、·296·中华实用诊断与治疗杂志2014年3月第28卷第3期JournalofChinesePracticalDiagnosisandTherapy·论著·铜绿假单胞菌注射液联合多西他赛和顺铂治疗肺癌所致恶性胸腔积液疗效观察李朋朋，邝先奎，董文杰，孙艳燕，李洁瑶，王丽萍(1．郑州大学第一附属医院肿瘤科，郑州450052；2．项城市第一人民医院肿瘤科，河南项城466200)摘要：目的观察铜绿假单胞菌注射液联合DP方案(多西他赛+顺铂)化疗治疗非小细胞肺癌所致恶性胸腔积液的效果及安全性。方法非小细胞肺癌并恶性胸腔积液患者66

2、例，随机分为观察组37例和对照组29例，2组均应用DP方案化疗2个周期。注射化疗药物7d后经B超证实胸腔积液排净或胸腔积液引流量<50mL／d时，观察组经胸腔灌注铜绿假单胞菌注射液，对照组经胸腔灌注白细胞介素一2。胸腔灌注治疗结束后6周评价2组疗效并观察不良反应发生情况。结果观察组有效率(89．2)高于对照组(69．0)(P<0．05)；观察组发热及胸痛发生率分别为43．2和48．6，对照组分别为为24．1和27．6，2组比较差异无统计学意义(P>O．05)。结论铜绿假单胞菌注射液胸腔灌注联合DP方案治疗非小细胞肺癌恶性

3、胸腔积液疗效满意，不良反应轻。关键词：非小细胞肺癌；恶性胸腔积液；铜绿假单胞菌注射液；化疗；白细胞介素一2TherapeuticeffectofPA—MSHAinjectionplusdocetaxelandcisplatincilonlungcancerinducedmalignantpleuraleffusionLIPeng—peng，KUANGXian—kui，DONGWen-jie，SUNYan—yan，LIJie—yao，WANGLi—ping(*DepartmentofOncology，theFirstAff

4、iliatedHospitalofZhengzhouUniversity，Zhengzhou450052，China)Abstract：ObjectiveToobservetheefficacyandsafetyofPA—MSHAinjectionplusdocetaxelandcisplatincil(DPscheme)inthetreatmentofmalignantpleuraleffusioninpatientswithnon—smallcelllungcancer(NSCLC)．MethodsSixty-six

5、NSCLCpatientscomplicatedwithmalignantpleuraleffusionwererandomlydividedintoobservationgroup(一37)andcontrolgroup(=29)．Bothgroupsreceived2cyclesofDPscheme．Whenultrasonographyshowednopleuraleffusionorthepleuraleffusionvolumewas1essthan50mL／dafterchemotherapyfor7days

6、，observationgroupwasgivenintrapleura1injectionofPA—MSHA，andcontrolgroupwasgivenintrapleuralinjectionofinterleukin-2．Theremissionrateandtoxicitieswereobserved6weeksaftertherapy．ResultsTheeffectiveratewas89．2％inobservationgroup，higherthanthatincontrolgroup(69．0)(P<

7、0．05)．Theincidenceratesoffeverandchestpainwere43．2and48．6inobservationgroup，showingnosignificantdifferencesincomparisonwithcontrolgroup(24．1，27．6)(P>0．05)．ConclusionsIntrapleuralinjectionofPA-MSHAcombinedwithDPschemeiseffectiveformalignantpleura1effusioninNSCLCpa

8、tients，andthetoxicityismild．Keywords：Non—smallcelllungcancer；malignantpleuraleffusion；PA—MSHAinjection；chemotherapy；interleukin-2恶性胸腔积液是晚期肺癌常见并发症，常导致胸l_1一般资料20