复方苦参注射液联合顺铂治疗恶性胸腔积液的临床效果-论文.pdf

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1、中国当代医药2014年9月第21卷第26期·药物与临床·复方苦参注射液联合顺铂治疗恶性胸腔积液的临床效果蒋剑湖南省永州市第三人民医院肿瘤科．湖南永州425000【摘要】目的探讨复方苦参注射液联合顺铂治疗恶性胸腔积液的临床效果。方法选取68例恶性胸腔积液患者，随机分为观察组与对照组，各34例，对照组采用注射顺铂治疗，观察组采用复方苦参注射液联合顺铂治疗。观察比较两组患者的近期疗效、生活质量改善情况(KPS评分)以及不良反发生情况。结果观察组治疗的总有效率为85．29％，明显高于对照组的61．76％，差异有统计学意义(O．05)；观察组患者治疗后的生活质量改善率为74．47％．对照组的生活

2、质量改善率为44．12％，组间差异有统计学意义(P

3、nantpleuralefusionjlANGJianDepartmentofOncology，theThirdPeopleSHospitalofYongzhouCityinHunanProvince，Yongzhou425000，China【Abstract]ObjectiveToinvestigatetheclinicaleffectofcompoundKusheninjectioncombinedwithcis-platinuminthetreatmentofmalignantpleuraleffusion．MethodsSixty-eightpatientswithmalign

4、antpleuraleffusionwereselectedasthestudysubjectsandweredividedintotheobservationgroupandthecontrolgroup，with34patientsineachgroup．Thecontrolgroupwerereceivedcis—platinuminjectiontreatment，theobservationgroupwerereceivedcompoundKusheninjectioncombinedwithcis-platinumtreatment．Theeficacy，theimprov

5、ementofqualityoflife(KPSscore)aswellastheoccurrenceofadversereactionsofthetwogroupswereobservedandcompared．ResultsThetotaleffectiverateoftheobservationgroupwas85．29％，whichwashigherthan61．76％ofthecontrolgroup，withsignificantdifferencef尸．<0．05)．Thepost-treatmentlifequalityimprovementrateoftheobser

6、vationgroupwas74．47％andthatofthecontrolgroupwas44．12％，withsignificantdifference(P<0．05)．Theincidenceofadversereactionsoftheobservationgroupwas29．41％，whichwaslowerthan55．88％ofthecontrolgroup，withsignificantdifference(氏0．05)．ConclusionTheappli·cationofcompoundKusheninjectioncombinedwithcis-platinu

7、minthetreatmentofmalignantpleuraleffusionhasre—markableeficacyandlowincidenceofadversereactions，caneffectivelyimprovethepatientsqualityoflife．【Keywords】Malignantpleuraleffusion；CompoundKusheninjeetion；Cis—platinum恶性胸腔积液是恶性肿瘤