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时间:2020-04-20
《奈达铂或顺铂联合氟尿嘧啶诱导化疗加同步放化疗治疗局部晚期鼻咽癌近期疗效的对比研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、1342重庆医学2013年4月第42卷第12期·临床研究·奈达铂或顺铂联合氟尿嘧啶诱导化疗加同步放化疗治疗局部晚期鼻咽癌近期疗效的对比研究崔建东,徐子海,张羽,龙桂宁,李涛,梁春林,闻世龙(解放军第三。三医院肿瘤科,南宁530021)摘要:目的观察奈达铂联合氟尿嘧啶诱导化疗加同步放化疗治疗局部晚期鼻咽癌治疗效果及安全性。方法74例局部晚期鼻咽癌患者随机分为实验组和对照组,每纽37例。实验组采用奈达铂联合氟尿嘧啶诱导化疗2个周期,14d后进行奈达铂同步放化疗;对照组采用顺铂联合氟尿嘧啶诱导化疗2个周期,14d后进行顺铂同步放化疗。结果治疗后3个月两组有效率均为100,
2、差异无统计学意义(P>O.05)。两组局部复发率、远处转移率、1年生存率相比差异均无统计学意义(P>O.05)。在治疗期间,实验组恶心、呕吐的发生率要明显低于对照组(P3、emiotherapywithnedaplatinorcisplatincombinedfluorouracilplusconcurrentchemoradiotherapyfortreatmentoflocallyadvancednas0pharyngealcarcinomaCuiJiandong,XuZihai,ZhangYu,LongGuining,LiTao,LiangChunlin,WenShilong(DepartmentofOncology。No.303HospitalofPLA,Nanning,Guang~ri53002l,China)Abstrac4、t:ObjectiveToevaluatetheefficacyandtoxicityofnedaplatinorcisplatincombinedwith5-fluorouracilinductionchemotherapyplusconcurrentchemoradiotherapy(CCRT)inthetreatmentoflocallyadvancednasopharyngea1carcinoma(NPC).MethodsTotal74patientswithlocallyadvancedNPCwererandomizedinto2cyclesofinduc5、tionchemotherapywithnedaplatinplus5-fluorouracilfollowedbynedaplatinconcurrentwithconformalradiotherapyafter14days(thetrialgroup,n一37)and2cy—clesofinductionchemotherapywithcisplatinplus5-fluorouracilfollowedbycisplatinconcurrentwithconformalradiotherapyafter14days(thecontrolgroup,n一37)6、.ResultsTheoverallresponserateswere100intwogroups,withnosignificantdifference(P>O.05).Therewerenosignificantdifferencesinlocoregionalrelapserateanddistantmetastasisrateandthe1yearoverallsur—vivalratebetweentwogroups(P>0.05).Theincidenceratesofnauseaandvomitinginthecontrolgroupweresigni7、ficantlyhigherthanthoseinthetrialgroupduringtreatment(P
3、emiotherapywithnedaplatinorcisplatincombinedfluorouracilplusconcurrentchemoradiotherapyfortreatmentoflocallyadvancednas0pharyngealcarcinomaCuiJiandong,XuZihai,ZhangYu,LongGuining,LiTao,LiangChunlin,WenShilong(DepartmentofOncology。No.303HospitalofPLA,Nanning,Guang~ri53002l,China)Abstrac
4、t:ObjectiveToevaluatetheefficacyandtoxicityofnedaplatinorcisplatincombinedwith5-fluorouracilinductionchemotherapyplusconcurrentchemoradiotherapy(CCRT)inthetreatmentoflocallyadvancednasopharyngea1carcinoma(NPC).MethodsTotal74patientswithlocallyadvancedNPCwererandomizedinto2cyclesofinduc
5、tionchemotherapywithnedaplatinplus5-fluorouracilfollowedbynedaplatinconcurrentwithconformalradiotherapyafter14days(thetrialgroup,n一37)and2cy—clesofinductionchemotherapywithcisplatinplus5-fluorouracilfollowedbycisplatinconcurrentwithconformalradiotherapyafter14days(thecontrolgroup,n一37)
6、.ResultsTheoverallresponserateswere100intwogroups,withnosignificantdifference(P>O.05).Therewerenosignificantdifferencesinlocoregionalrelapserateanddistantmetastasisrateandthe1yearoverallsur—vivalratebetweentwogroups(P>0.05).Theincidenceratesofnauseaandvomitinginthecontrolgroupweresigni
7、ficantlyhigherthanthoseinthetrialgroupduringtreatment(P
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