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ID:5365561
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时间:2017-12-08
《年龄因素对肝癌肝切除术患者长期预后的影响_苗润晨》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、网络出版时间:2014-04-2409:39现代网络出版地址:肿瘤医学201http://www.cnki.net/kcms/doi/10.3969/j.issn.1672-4992.2014.05.44.html4年5月第22卷第5期MODERNONCOLOGY,May2014,VOL22,NO05·1123·BOJ,2004,23:3270-3281.[11]MillerJK,ShattuckDL,IngallaEQ,etal.Suppressionofthenega[10]StutzMA,Shattuc
2、kDL,LaederichMB,etal.LRIG1negativelytiveregulatorLRIG1contributestoErbB2overexpressioninbreastregulatestheoncogenicEGFreceptormutantEGFRvIII[J].Oncancer[J].CancerRes,2008,68:8286-8294.cogene,2008,27:5741-5752.(编校:谈静)年龄因素对肝癌肝切除术患者长期预后的影响苗润晨,许鑫森,陈伟,周延岩,万永,吕毅,刘昌T
3、heeffectofageonlong-termprognosisofpatientswithhepatocellularcarcinoma(HCC)afterresectionsurgeryMiaoRunchen,XuXinsen,ChenWei,ZhouYanyan,WanYong,LvYi,LiuChangDepartmentofHepatobiliarySurgery,TheFirstAffiliatedHospitalofMedicalCollege,Xi'anJiaotongUniversity,Shaa
4、nxiXi'an710061,China.【Abstract】Objective:AgeplaysanimportantroleontheprognosisofpatientswithHCCafterresectionsurgery.Whetherolderpatientsshouldreceiveresectionsurgeryremainscontroversial.Weaimtocomparetheclinicopathologicalfeaturesandprognosesbetweenyoungerand
5、olderpatientswithHCCundergoingresection.Methods:Theclinicalrecordsof172patientswithhepatocellularcarcinomaundergoingresectionsurgerywereanalyzedretrospectively,andthefollow-upofthesepatientswasperformed.Weinvestigatedthecorrelationbetweenthefactorofageandthecli
6、nicopathologicalfeaturesorprognoses.Results:Theyoungerpatients(≤53)hadbetterliverfunctionalreservebutmoreaggressivetumorfactorsthantheolderpatients(>53).Afteramedianfollow-upof31months,87patientsdied.Thecumulative5-yearsurvivalrateswere55.43%inyoungerpatientsa
7、nd48.31%intheolderpatients(P=0.026).Usingmultivariateanalysis,wedemonstratedthatagewasanindependentriskfactorassociatedwithoverallsurvival.Besides,therewere76patientswhohadtumorrecurrenceaftersurgery.Usingmultivariateanalysis,wefailedtofindthattheincidenceoftum
8、orrecurrenceinyoungerpatientswascomparabletothatintheolderpatients.Conclusion:AgeisariskfactortodeterminethesurvivalofpatientswithHCCwhounderwentresection.However,nocorrelat
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