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1、米索询列醇用于人工流产术前宫颈扩张的临床观察【关键词】人工流产术【摘要】目的探讨II服米索前列醇用于人工流产术前宫颈软化扩张的适宜给药剂量。方法采用前瞻性対比研究,将250例早孕妇女随机分为51:1纽,米索前列醇200ug术前lh口服;2组,米索前列醇400Pg术前lh口服;3组,单用1%利多卡因于宫颈3点、9点处齐注射2ml;4纽.,米索前列醇200Pg术前lh口服配伍1%利多卡因宫颈3点、9点处各注射2ml;5纽.,术前不予任何药物。观察并比较齐组宫颈松弛程度、扩宫难易度、手术效果、疼痛程度、术前术后宫腔长度差、手术时出血量及人流综合征等参数。
2、结果1、2、4组在术前宫颈松弛度和扩宫难易度方面差异无显著性(P>0.05)o而]、2、3、4组与5组比较差异具有非常显著性(P=0.000),1、2、4纽与3纽•比较在宫颈松弛度方面差异有显著性(P<0.05),在扩宫难易度方面差异无显著性(P>0.05)o宫缩效果以及疼痛评分比较:1、2、4组比较差异无显著性(P>0.05),1、2、4纽.与3纽之间差异有非常显著性(P=O.OO7、P=O.OO8、P=0.007);]、2、3、4组与5组比较差异有非常显著性(P=0.000)o宫腔长度差及出血量在1、2、3、4、5纽之间差异均无显著性(P>0.
3、05)°1、2、4组均尢人流综合征发生,3组1例发生人流综合征,5组3例发生人流综合征.结论人工流产术前口服米索前列醇可以有效地软化扩张宫颈,减少受术者痛苦;术前服用200ug与4OOug可以同样有效地软化扩张宫颈。关键词人工流产术米索前列醇宫颈扩张TheoptimaldosageoforalmisoprostolforcervicalpriminginartificialabortionHeKe,LiuDongqing,YuLiyunTheFirstAffiliatedHospitalofSunYet-SenUniversity,Guangzho
4、u510080・[Abstract]ObjectiveTodeterminetheoptimaldosageoforalmisoprostolforcervicalpriminginfirst-trimestervacuumartificialabortion.MethodsAprospectivestudywascarriedoutwith250healthywomenrequiringlegalterminationofpregnancybetween6to1Oweeksofgestation.Theywererandomlyallocated
5、into5groups:1:miso-prostol200
6、igorallytaken1hourbeforeoperation;2:misoprostol400(igorallytcikenlhourbeforeoperation;3:lido-caine4mlcervixinjection5minutesbeforeoperation;4:misoprosto!200Ugorallytaken1hourbeforeandlidocaine4mlcervixinjection5minutesbeforeoperation;5:nomedicatio
7、nbeforeoperation.CervTicalrelaxation,cervicaldilationdegree,pelvicpain,cavitylengthdifferencebetweenpre-andpost-operation,bloodloss,operationeffectandoccurrenceofRAASwereobserved.ResultsTherewasnosignificantdifferenceincerx-icalrelaxationandcervicaldilationdegreeamonggroup1,2a
8、nd4(P>0.05)whilesignificantlydifferentfromgroup3.Theoperationeffectwasbetteringroup1,2,3,4whencomparedwithgroup5(P=0.000).Therewasnosignificantdifferenceinoperationeffectandpelvicpainbetweengroup1and2(P>0.05).Therewasnodifferenceincavitylengthandbloodlossamongthese5groups.NoRA
9、ASoccurredingroup1,2,4withleaseingroup3and3ingroup5.Conclusio