米索前列醇用于人工流产术前宫颈扩张的临床观察

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1、米索前列醇用于人工流产术询宫颈扩张的临床观察【关键词】人工流产术【摘要】目的探讨口服米索前列醇用于人工流产术前宫颈软化扩张的适宜给药剂量。方法采用前瞻性对比研究，将250例早孕妇女随机分为5组:1组，米索前列醇200ug术前lh口服;2组，米索前列醇400Pg术前lh口服;3组，单用1%利多卡因于宫颈3点、9点处各注射2ml;4组，米索前列醇200Pg术前lh口服配伍1%利多卡因宫颈3点、9点处各注射2ml;5组，术前不予任何药物。观察并比较各组宫颈松弛程度、扩宫难易度、手术效杲、疼痛程度、术前术后宫腔长度差、手术时出血量及人

2、流综合征等参数。结果1、2、4组在术前宫颈松弛度和扩宫难易度方曲差异无显著性(P>0.05)o而1、2、3、4组与5组比较差异具有非常显著性(P=0.000),1>2、4组与3组比较在宫颈松弛度方而差异有显著性(PvO.05),在扩宫难易度方面差异无显著性(P>0.05)o宫缩效果以及疼痛评分比较:1、2、4组比较差异无显苦性(P>0.05),1、2、4组与3组之间差异右非常显苦性(P=0.007、P=0.008、P=0.007);1、2、3、4组与5组比较差异有非常显著性(P=0.000)o宫腔长度差及出血量在1、2、3、4

3、、5组之间差异均无显著性(P>0.05)o1>2、4组均无人流综合征发生，3组1例发生人流综合征，5m3例发生人流综合征。结论人工流产术前口服米索前列醇可以有效地软化扩张宫颈，减少受术者痛苦;术询服用20()ng与400ug可以同样有效地软化扩张宫颈。关键词人工流产术米索前列醇宫颈扩张TheoptimaldosageoforalmisoprostolforcervicalpriminginartificialabortionHeKe,LiuDongqing,YuLiyunTheFirstAffiliatedHospitalof

4、SunYet-SenUniversity,Guangzhou510080.[Abstract]ObjectiveTodeterminetheoptimaldosageoforalmisoprostolforcervicalpriminginfirst-trimestervacuumartificialabortion.MethodsAprospectivestudywasearnedoutwith250healthywomenrequiringlegalterminationofpregnancybetween6to1Owee

5、ksofgestation.Theywererandomlyallocatedinto5groups:1:miso-prostol200pgorallytaken1hourbeforeoperation;2:misoprostol400pgorallytaken1hourbeforeoperation;3:lido-caine4mlcervixinjection5minutesbeforeoperation;4:misoprostol200ugorallytaken1hourbeforeandlidocaine4mlcervi

6、xinjection5minutesbeforeoperation;5:nomedicationbeforeoperation.Cervicalrelaxation,cervicaldilationdegree,pelvicpain,cavitylengthdifferencebetweenpre-andpost-operation,bloodloss,operationeffectandoccurrenceofRAASwereobserved.ResultsTherewasnosignificantdifferenceinc

7、ervicalrelaxationandcervicaldilationdegreeamonggioup1,2and4(P>0.05)whilesignificantlydifferentfromgroup3.Theoperationeffectwasbetteringroup1,2，3,4whencomparedwithgroup5(P=0.000).Therewasnosignificantdifferenceinoperationeffectandpelvicpainbetweengroupland2(P>0.()5)・

8、Therewasnodifferenceincavitylengthandbloodlossamongthese5groups.NoRAASoccurredingroupL2,4withleaseingi-oup3and3ingroup5.ConclusionEither20