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时间:2020-04-02
《氧氟沙星联合卷曲霉素治疗耐多药肺结核观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、.2784.吉林医学2010年6月第31卷第18期与病死率直接相关,APACHEⅡ分值以5分阶递增,病死率显著[1]沈洪.对危重患者预后指标的量化性评价[J].中华急诊医学杂增加。孙师元认为APACHEⅡ分值≥20分时,死亡危险度明显增志,2002,2,11(1):64.[3]加,对此应加强监护,及早调整治疗方案。将APACHEII评分[2]胡宁利.我国危重疾病评分系统应用现状[J].中国危重病急救医应用到死亡患者,可明显降低低APACHEII评分患者的死亡,值学,2001,13(2):73.得推广。[3]孙师元.APACHEII评分系统对机械通气患者预后病情评估[J].河北医药,20
2、03,5(2):342.4参考文献[收稿日期:2010-03-27编校:周瑾]氧氟沙星联合卷曲霉素治疗耐多药肺结核观察李史来(广东省汕头市第三人民医院,广东汕头515073)[摘要]目的:探讨氧氟沙星联合卷曲霉素治疗方案治疗耐多药肺结核的效果。方法:回顾性分析162例耐多药肺结核病例资料,与同期氧氟沙星和其他抗结核药联用病例对照分析。结果:两组病例疗程结束时,观察组痰菌阴转率明显高于对照组,两组比较差异有统计学意义(P<0.01);观察组空洞转阴率高于对照组,两组比较差异有统计学意义(P<0.01);观察组病灶明显吸收率高于对照组,两组比较差异有统计学意义(P<0.05);观察组复发率
3、与对照组比较差异有统计学意义(P<0.05);观察组的药物不良反应率与对照组比较差异无统计学意义(P>0.05)。结论:氧氟沙星与卷曲霉素的配合治疗能明显提高耐多药肺结核的治疗效果,复发率低,值得临床推广。[关键词]氧氟沙星;卷曲霉素;肺结核;耐多药Ofloxacincombinedcapreomycintreatmentobservationofmulti-drugresistanttuberculosisLIShi-lai(GuangdongProvince,theThirdPeople'sHospitalofShantou,Shantou515073)Abstract:Objec
4、tiveOfloxacininthetreatmentofcombinedcapreomycininthetreatmentoftheeffectofmulti-drugresistanttuberculosis.MethodsRetrospectiveanalysisofourhospitalduringthe162patientsadmittedtoclinicaldataofmulti-drugresistanttuberculosis.Withthesameperiodofofloxacinandotheranti-TBdrugsinconjunctionwiththecase
5、-controlanalysis.ResultsThetwogroupsweretheendoftreatment,sputumconversionrateoftheobservationgroupwassignificantlyhigher,thedifferencewasstatisticallysignificant(P<0.01);observationgroupemptynegativeratewashigher,thetwogroupsTherewassignificantdifference(P<0.01);observationgrouplesionssignifica
6、ntlyhigherabsorptionrate,thedifferencewasstatisticallysignificant(P<0.05);observationgroupandcontrolgrouprecurrenceratewassignificantly(P<0.05);observationgrouptherateofadversedrugreactionscomparedwiththecontrolgroupshowednosignificantdifference(P>0.05).ConclusionCapreomycinwithOfloxacinandthetr
7、eatmentcouldsignificantlyincreasethemulti-drugresistanttuberculosistreatment,relapserateislow,worthytobepopularized.Keywords:Ofloxacin;Capreomycin;Tuberculosis;Multi-drugresistant结核病是古老的传染性疾病,耐药结核病(DR-TB)是指患1例。对照组81例,男52例,女2
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