人工肝治疗戊型肝炎合并高胆红素血症

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1、肝胆病杂志2010年第鲞397人7-1]：t：治疗戊型肝炎合并高胆红素血症苟卫，陈美珠，王燕玲，赵文革(青岛市传染病医院，山东青岛266033)【摘要】目的观察人工肝(ALSS)治疗戊型肝炎合并高胆红素血症的临床疗效。方法在内科综合治疗的基础上，采用人工肝治疗52例戊型肝炎合并高胆红素血症患者，并随机选择43例戊型肝炎合并高胆红素血症患者作为对照组，评价临床疗效并观察治疗前后TBil、AST、AlJT、ALB、BUN、Cr及PTA等指标。结果经人工肝治疗后84．62％患者原有的乏力、恶心呕吐、食欲等症状明显改善；治疗后治疗组血清中AlJT较对照组显著下降

2、(P<0．05)，A、ALB明显上升(P<0．05)，BUN、Cr无明显差异。治疗组戊型肝炎合并高胆红素血症治愈好转率为84．62％(44／52)；对照组治愈好转率为55．81％(24／43)，两组比较有统计学差异(P<0．05)。结论在内科综合治疗基础上，及时采用人工肝辅助治疗，能提高戊型肝炎合并高胆红素血症患者治愈好转率。还可以通过TBil反弹的现象来判断患者的预后。【关键词】肝，人工；肝炎，戊型；高胆红素血症【中图分类号】R512．62【文献标识码】A【文章编号】1001—5256(2010)04—0397—03Theefectofartifici

3、alliversupportsystemonthetreatmentofhepatitisEvirusinfectioncomplicatedbyhyperbil-irubinemiaGOUWei，CHENMei—zhu，WANGYan—ling，eta1．(DepartmentofLiverDisease，TheInfectiousDiseasesHospitalofQingdao，Qingdao，Shandong266033，China)Abstract：ObjectiveToinvestigatetheeffectofartificialliver

4、supportsystem(ALSS)onthetreatmentofhepatitisEvi—rusinfectioncomplicatedbyhyperbilirubinemia．MethodsAtotalof52patientswithhepatitisEvirusinfectioncomplicat—edbyhyperbilirubinemiaweretreatedwithartificialliversuppo~systemonthebasisofconventionaltherapy．43patientswereincludedinthest

5、udyasacontro1．ClinicalparametersincludingserumTBIL，AST，ALT，BUN，ALB，PTAandCrweremeasured．ResultsTheclinicalsymptomsofhepatitisEpatientscomplicatedbyhyperbilirubinemiawereimproveda—mongthetreatmentgroup．TheserumlevelsofTBIL，ATL，AST，TBA，ALBandPTAincreasedsignificantly(P<0．05)．Nostat

6、isticalsignificancewasobservedinthelevelsofBUNandCr．Thetreatmentresponseswere84．62％and55．8】％inthetreatmentgroupandinthecontrolgroup，respectively(尸<0．05)．ThelevelofseFumTBILincreasedonlyinsevenpatients．ConclusionTheALSSiseffectiveintreatinghepatitisEvirusinfectioncomplicatedbyhype

7、rbilirubi—nemiaonthebasisofconventionaltherapy．TheincreaseintheserumlevelofTBILcanusedtOmonitortheprognosisofhepatitisEvirusinfectioncomplicatedbyhyperbilirubineafiaafterALSStreatment．Keywords：liver，artificial；hepatitisE，hyperbilirubinemia戊型肝炎(戊肝)是临床常见的病毒性肝炎之50．82岁。对照组43例，男38例，女5

8、例，年龄37一，一般认为好发于青壮年，它易发展至重型肝炎。～79岁，平均49．6