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1、亚低温治疗重型颅脑损伤患者临床疗效观察及其安全性评价亚低温治疗重型颅脑损伤患者临床疗效分析及对患者血清GFAP、UCH・L1、NSE、CRP水平的影响摘要目的：探讨亚低温治疗重型颅脑损伤患者临床疗效分析及对患者血清GFAP、UCH・UL、NSE、CRP水平的影响。方法：106例重型颅脑损伤患者根据随机分组法分为治疗组(n=53)和对照组(253)。对照组给予常规治疗，治疗组在对照组基础上结合亚低温治疗。对比分析两组入院时、治疗后Id和治疗后5d颅内压、血糖、血清GFAP、UCH-L1>NSE、CRP指标变化以及治疗6个月后预后情况
2、。结果：两组颅内压第“、第5d颅内压较入院时明显降低(P<0.05)；治疗组颅内压治疗后Id、5d颅内压明低于对照组(P<0.05)；两组第Id、第5d血糖水平显著低于入院时(P&t;0.05)；治疗组治疗后Id、5d血糖水平显著低于同期对照组(P<0.05)；两组血清GFAP、UCH-L1水平治疗后Id、5d较入院时显著降低(P<0.05)；治疗组血清GFAP、UCH-L1水平治疗后Id、5d显著低于对照组(P<0.05)；两组NSE、CRP治疗前变化比较无统计学差异(P>；0.05)；治疗组N
3、SE、CRP治疗后Id和5d明显低于同期对照组(P<0.05)；治疗组良好率显著高于对照组(P<0.05),死亡率显著低于对照组(P<0.05)；而两组中残、重残及植物状态对比无统计学差异(P>；0.05)o结论：亚低温治疗重型颅脑损伤患者临床疗效显著，降低血清GFAP、UCH-L1>NSE、CRP水平，改善患者预后，值得进一步推广应用。关键词：亚低温；重型颅脑伤；疗效；GFAP；UCH-L1；NSE；CRPHypothermiatreatmentofclinicalefficacyinpatientswit
4、hseverebraindamageinpatientswithserumindicatorsofGFAP^CH-Ll,NSE；CRPlevelsAbstractObjective:ToinvestigatetheclinicaleffectofmildhypothermiaonpatientswithseverecraniocerebralinjuryandtheeffectofserumGFAP,NSE,UCH・L1andCRPlevelsinpatientswithsevereeraniocerebralinjury.Met
5、hods:106casesofseveretraumaticbraininjurypatientsaccordingtorandomizeddividedintotreatmentgroup(n=53)andcontrolgroup(n二53).Thecontrolgroupreceivedconventionaltreatmentgroupcombinedwithhypothermiawerebasedon.Comparativeanalysisoftwohospitalized,5dintracranialpressure,b
6、loodglucose,serumGFAP,UCH-L1,NSE,CRPlevels,cerebrovascularIndexesIdaftertreatmentandtherapyand6monthspost-treatmentprognosis.Results:Thereintracranialpressureonldz5dsignificantlylowerintracranialpressurecomparedwiththefirstadmission(P<0.05);intracranialpressurether
7、apytreatmentgroupId,5dMingintracranialpressurethanthecontrolgroup(P<0.05);twopairsofId,paragraph5dsignificantlylowerbloodglucoselevelsatadmission(P<0.05);Id,5dglucoselevelsinthetreatmentgroupwassign讦icantlylowerthanthatinthecontrolgroup(P<0.05);levelsofserumG
8、FAP,UCH-L1levelsAftertreatment,Id,whenadmissionwassigrdficantlylowerthanthe5d(P<0.05);treatmentserumGFAP,UCH-L1levelsafte
