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1、VIROLOGY243,150±157(1998)ARTICLENO.VY989045FelineInfectiousPeritonitisVirusesArisebyMutationfromEndemicFelineEntericCoronaviruses,1,2,HarryVennema,*AmyPoland,*JanetFoley,*andNielsC.Pedersen*²*CenterforCompanionAnimalHealthandthe²DepartmentofMedicineandEpidemiology,SchoolofVeterinaryMedicine,Univer
2、sityofCaliforniaatDavis,DavisCalifornia95616ReceivedJune11,1997;returnedtoauthorforrevisionJuly2,1997;acceptedJanuary14,1998Felineinfectiousperitonitisvirus(FIPV)strainsfromsixcatsandthreedifferentgeographicareaswerecomparedgeneticallywithfelineentericcoronavirus(FECV)isolatesobtainedfromcatsinhab
3、itingthesameenvironments.Sequencecomparisonsweremadefrom1.2-to8.9-kbsegmentsonthe39endofthegenome.FECV/FIPVpairsfromthesamecatteriesorshelterswere97.3±99.5%relatedbutweregeneticallydistinctfromFIPVandFECVstrainsobtainedfromcatslivingingeographicallydistinctenvironments.Thehighgeneticsimilaritybetw
4、eenFECVsandFIPVsfromthesameenvironmentstronglysuggestedacommonancestry.BasedonthepresenceofdeletionmutationsintheFIPVsandnotintheFECVs,itwasconcludedthatFIPVsevolvedasmutantsofFECVs.ThemutationsaredeletionsintheFIPVsandnotinsertionsintheFECVssincesimilarsequencesarepresentinotherstrainsthathaveseg
5、regatedearlierfromacommonancestor.Therefore,theorderofdescentisfromFECVtoFIPV.MutationsuniquetoFIPVswerefoundinopenreadingframes(ORFs)3cin4of6isolatesand/or7bin3of6isolates.Whenthestudywasextendedtoinclude7additionalFIPVisolates,11/13oftheFIPVssequencedwerefoundtohavemutated3cORFs.©1998AcademicPre
6、ssINTRODUCTIONenteritis.Itwaspostulated,therefore,thatFIPVmightbearelativelycommonandhighlypathogenicmutantoftheFelineinfectiousperitonitis(FIP)isahighlyfatalinfec-moreubiquitousFECV(Pedersenetal.,1984)(Pedersentionofcats.ThediseasewasfirstrecognizedintheandFloyd,1985).Thevalidityofthismutationalt
7、heory1950s(Holzworth,1963)andiscurrentlytheleadingwasquestionedwhenso-calledprototypictissuecul-infectiouscauseofmortalityinyoungcatsfrompedi-ture-adaptedstrainsofFIPV(strainWSU79-1146)andgreedcatteriesandshelter
