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1、J.smallAnim.Pract.(1978)19,623-630.Felineinfectiousperitonitis:acoronavirusdiseaseofcatsM.C.HORZINEKANDA.D.M.E.OSTERHAUSInstituteofVirology,StateUniversity,Utrecht,TheNetherlandsABSTRACTInfectionsofcatswiththecoronaviruscausingfelineinfectiousperitonitis(FIP)aremostlyinapparent.Inca
2、seswhereapoly-serositisdevelops,itisaprogressivelydebilitating,fataldiseasewithoccasionalneurologicalandocularsymptoms.Uponpost-mortemexamination,pyogranulomatousorganlesionsareprominent;thebodycavitiesmaycontainvaryingquantitiesofaviscidexudate.Theagent,whichisserologicallyrelatedt
3、oTGEvirusofswine,hasaworldwidedistribution.Ithasbeenshownrecentlytoreplicateinlaboratoryrodents.SeveralobservationsindicateanimmunepathogenesisofFIP.INTRODUCTIONFelineinfectiousperitonitis(FIP)isavariablyprogressive,usuallyfatalcondi-tion,affectingdomesticandwildFelidae,whichischara
4、cterizedbyfever,anor-exia,depressionandascites.Themostprominentfeaturesuponpost-mortemexaminationarediffusefibrinousperitonitis,mesothelialhyperplasiaandfocalnecrosisinparenchymatousorgans.TheaetiologicalagentisavirusbelongingtotheCoronaviridaefamily,whichisantigenicallyrelatedtotra
5、nsmissiblegastroenteritis(TGE)virusofswine.Inthepresentarticleashortreviewisattemptedoftheclinical,pathologicalandepidemiologicalaspectsofthedisease;specialattentionisgiventothecharacterizationofFIPviruswhichhasbeensubjecttointensivestudyintheauthor’slaboratoryduringthelast2years.Di
6、seasedescription(a)ClinicalFindings.FIPisobservedataboutthesamefrequencyincatsofall0020-4510/78/1I00-0623$02.0001978BSAVA623624M.C.HORZINEKANDA.D.M.E.OSTERHAUSages(Robison,Holzworth&Gilmore,1971),breeds(Hardy&Hurvirz,1971;Ward&Pedersen,1969)andinbothsexes(Pedersen,1976c;Ward&Pederse
7、n,1969).Theclinicalsymptomsofthediseasearenotverycharacteristic:initially,theaffectedanimalshowsanorexia,elevatedrectaltemperatureandgeneraldepressionwhichmaypersistoveralongerperiodoftime;inclassicalcasesthesesymptomsareaccompaniedbyagradualabdominaldistensionwhich,incom-binationwi
8、thaprogressiveemaci
