冠状病毒Coronavirusl论文-1984 Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection.pdf

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1、JournalcfNeuroimmunology,6(1984)325-37632.$ElsevierJNI00195RelapsingSubacuteDemyelina~:ingEncephalomyelitisinRatsduringtheCourseofCoronavirusJHMInfectionHelmutWege,RihitoWatanabeandVolkerterMeulenInstituteofVirologyandlmmunobiology,UnioersityofWfirzbur~D.8700W~rzburg(ER/~.)(Received26August,1

2、983)(Revised,received1December,1983)(Accepted20December,1983)SmTemperature-sensitivemutantsofthemunnecoronavirusJHMinducedasub~acutedemyelinatin8encephalomyelitis(SD~E)inyoun~rats.Neurologicalsymptol~,;wereassociatedwithmarkedlesion3ofprimaryd~my¢;lination".mthewhitematterofthecentralnervouss

3、ystem(CNS),anddevelopingafteranincubationtimeofseveralweekstomonths.Manyratssurvivedthisinfectionandrco3veredcompletelyfromthisCNSdisease.Amon843survivorsofSDE,9ra'~sdevelopeda~'elapse27-153daysafteronsetofthefirstattack.Neuropathologica.lex~n~ationol~theseanimalsrevealedareasoffresh

4、¢~emyeli

5、nationtogetherwitholdremyelinatedlesions.V'mdantisensweredetectableintheneighbourhoodoffreshles:ionsandinsomeca~infectiousviruswasre-i~latedfromratsrevealinglowantibl~ytiterstoJHMvirus.TheseresultsdemonstratethatmutantsofJHMviruscaninduca~arelapsingdemyelinatingdiseaseprocess,associatedwithap

6、ersistentinfection,whichsomesimilaritiestochronicexperimentalallergicenceph~dor~ayel/tis.Keywords:Autoimmunereaction-CoronavirusJHM-L~emyelination-Experi-mentalallergicencephalomyelitis(EAE)-P~'rsisJ'entinfectionRelapsingden~yefinationisanimportantfeatureofcertainchroniccentralnervoussystem(C

7、NS)diseas~inbothanimalandmanforwhichetiol08:land/orThiswork~'usup,oortedbytheDeutscheForschungsgemeinscheftandHumbo~tdt-Stiftun&0165-5728/83,/$03.0001983ElsevierSciencePublishersB.V.326pathogenesisareunknown.Themostprominentexampleismultiplesclerosis(MS)whichisthoughttobeassociatedwithanimmun

8、epathologicalprocessp~siblyactinginconcertwithavirusinfection(Waksman1981).IthasbeenshownthatanautoimmunereactionagainstCNStissuecanleadto6hronicrelapsingdemyelina-tionasseeninchronicexperimentalallergicencephalomyelitis(EAE)whereastheroleofa