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1、NeuropathologyandAppliedNeurobiology1984,10,17S184SEQUENCEOFMURINECORONAVIRUSJHMINDUCEDNEUROPATHOLOGICALCHANGESINRATSM.KOGA",H.WEGEANDV.TERMEULENYInstitutfurVirologieundImmunbiologiederUniversitatWurzburg,VersbacherStrasse7,D-8700Wurzburg,GermanyAcceptedforpublication29November1983KogaM.,
2、WegeH.8zterMeulenV.(1984)NeuropathologyandAppliedNeurobiology10,173-184SequenceofmurinecoronavirusJHMinducedneuropathologicalchangesinratsInfectionof21-25-day-oldratswiththemurinecoronavirusJHMwasfollowedeitherbyanacuteencephalomyelitis(AE)orsubacutedemyelinatingencephalomyelitis(SDE).The
3、majorneuropathologicalfindinginAE,whichdevelopedwithin6-12dayspi.consistedofnecrotizinglesionsdistributedmainlyinthegreymatterofthecentralnervoussystem(CNS).SDEdeveloped14-30dayspi.andaffectedratsrevealedlesionsofprimarydemyelinationwithpredilectionsitesinthewhitematter.Thetime-coursefort
4、hedevelopmentoflesions,virusreplicationandneutralizingantiviralantibodyproductionwithinthefirst3weeksp.i.werestudied.Withinthefirst2weeksp.i.,mostratsshowednoclinicalsignsbutneverthelessrevealedlesionstypicalofAE.Inparalleltotheseneuropathologicalchangesinfectiousviruscouldbeisolatedfromb
5、rainandspinalcord.However,coincidingwithmultiplicationofneutralizingJHMantibodiesl(f12daysafterinfectionnoinfectiousviruswasrecoverablefromCNSmaterial.AtthistimemanyoftheclinicallyhealthyratsshoweddemyelinatinglesionswhichwerelocatedatthetypicalpredilectionsitesofSDE.Theseobservationsindi
6、catedthatSDEwasprecededbyclinicallysilentAElesions.IntroductionInvestigationsofcentralnervoussystem(CNS)diseasesinmanandanimalshaveshownthatvirusescaninducedemyelinationbyvariousmechanisms(Weiner&Stohlman,1978;terMeulen&Hall,1978).Onepossiblewayisthedirecteffectofvirusreplicationleadingto
7、destructionofoligodendrogliacells.Inadditionviruses,ortheirproducts,maycausedemyelinationby*Presentaddress:DepartmentofPathology,SagaMedicalSchoolNabeshima,Saga,Japan.tCorrespondenceto:V.terMeulen.173174M.Koga,H.WegeandV.terMeulendirectdamagetomyelinmembranes,sincef
