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1、JournalofNeuroimmunology,48(1993)81-9081©1993ElsevierSciencePublishersB.V.AIIrightsreserved0165-5728/93/$06.00JNI02451/3-EndorphinprotectsmicefromneurologicaldiseaseinducedbythemurinecoronavirusMHV-JHMWendyGilmore*andDorisS.MoradzadehDepartmentofNeurology,MCK142,USCSchoolof
2、Medicine,1333SanPabloSt.,LosAngeles,CA90033,USA(Received30November1992)(Revisionreceived27May1993)(Accepted27May1993)Keywords:Murinecoronavirus;Paralytic-demyelinatingdisease;/3-Endorphin;Immune-mediatedCNSdiseaseSummaryTheneurotropicmurinecoronavirus,MHV-JHM(JHMV)causesenc
3、ephalitisandparalytic-demyelinatingdiseaseinsusceptiblestrainsofmiceandrats,servingasamodelforhumandemyelinatingdiseasessuchasmultiplesclerosis.Inthiscommunication,wereportthatasingleintracerebraladministrationofthenaturallyoccurringneuropeptide,fl-endorphin,reducedtheincid
4、enceofJHMV-inducedparalytic-demyelinatingdisease40-50%inC57B1/6mice.Protectionfromdiseasewasaccompaniedbysignificantlyreducedvirusreplicationinthebrainasearlyas3dayspost-infectionanddidnotoccurinirradiated,orimmunoincompetentmice.Thedatasuggestthatfl-endorphinengagesimmunem
5、echanismsofhostresistancetoJHMVinfectiontoprotectthemicefromdisease.Introductionstrainsinwhichspecificgeneticchangesareassociatedwithalteredencephalitogenicordemyelinatingpoten-Theneurotropicstrainofmousehepatitisvirustial(Haspeletal.,1978;Knobleretal.,1982;KoolenetknownasM
6、HV-4-JHM(JHMV)causesacuteen-al.,1983;LaMonicaetal.,1991).OneoftheJHMVcephalitisaccompaniedbyacuteandinsomecasesmutantvirusesthathasbeenstudiedindetailisthechronicparalytic-demyelinatingdiseaseinsusceptibleneutralization-resistantstrain,2.2-V-1,whichwasse-strainsofmiceandrat
7、s(Cheeveretal.,1949;Weiner,lectedusingamonoclonalantibodyspecificforthe1973;Lampertetal.,1973;Sorensenetal.,1980,spike(S)glycoproteinofJHMV(Flemingetal.,1986,Knobleretal.,1981;Wegeetal.,1981;DalCantoand1987).Theclinicalandhistopathologicalcourseof2.2-Rabinowitz,1982;Buchmei
8、eretal.,1988).IthasbeenV-1infectionduringthefirst2weeksfollowingi.c.usedextensivel
