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1、perpolarizationwithnoapparentcenter-sur-74P(1983);D.A.Burkhardt,G.Hassin,J.S.frominfectedanimalsincubatedwithroundantagonisticpolarization.Anelectronmi-Levine,E.F.MacNichol,Jr.,ibid.309,215preimmuneserum.However,antigen-croscopicstudyofserialsectionsrevealedthat(1980)].about30percentoftheret
2、inalcells,whose17.IthankA.Kaneko,A.T.Ishida,andR.Simin-positivecellswereclearlyseeninsec-somatawerelocatedintheouternuclearlayer,offfordiscussionsandcomments;L.E.Lipetzweredisplacedbipolarcells(N.Kouyamaandfordataonvisualpigments;W.W.StewartfortionsfrominfectedanimalsincubatedT.Ohtsuka,Brain
3、Res.,inpress).thegiftofLuciferyellowCH;andH.Maebashiwiththeantiserum.Thenumberofim-16.Similarresultshavealsobeenreportedinotherfortechnicalassistance.vertebrateretinas[D.I.Attwell,F.S.Werblin,munoreactivecellswascloselyrelatedtoM.Wilson,S.M.Wu,J.Physiol.(London)341,16November1984;accepted23J
4、uly1985theclinicalseverityoftheencephalitisandtheintervalbetweeninoculationanddeath.ViralantigenswerepresentinthebrainingreatestamountswithinthefirstInfectionoftheBasalGangliabyaMurineCoronavirus2weeksafterinoculation.Inallanimalsinwhichsufficientnumbersofantigen-Abstract.Thecoronavirus,mous
5、ehepatitisvirusstrainA59(MHV-AS9),causespositivecellswerepresentfortheirdis-mildencephalitisandchronicdemyelination.Immunohistochemicaltechniquestributiontobeassessed(12of19animalsshowedthatMHV-A59-infectedC57BL/6micecontaineddensedepositsofviralexamined),adiscreteclusterofinfectedantigenint
6、hesubthalamicnucleusandsubstantianigra,withfewersignsofcellswasconsistentlyfoundinthedien-infectioninotherregionsofthebrain.Theanimalsshowedextra-andintracellularcephalonintheregionofthesubthalamicvacuolation,neuronalloss,andgliosisinthesubthalamic-nigralregion.Suchnucleusandtheadjacentsubst
7、antiani-localizationisunprecedentedamongknownviralencephalitidesofhumansandgra.Alow-powerviewofsuchanareaotherspecies.Thisinfectionbyamemberofaviralclasscapableofcausingboth(Fig.IA)illustratesthediscretelocaliza-encephalitisandpersistentinfectionin
