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1、血清总胆汁酸测定诊断妊娠肝内胆汁淤积症的临床意义分析［摘要］目的分析血清总胆汁酸(TBA)测定诊断妊娠肝内胆汁淤积症(ICP)的临床意义。方法选取本院收治的42例ICP孕妇作为观察组,另选择同期体检的40例健康孕妇为对照组，分别检测两组孕妇的血清TBA、ALT、AST、TBiL水平,并对比分析两组孕妇血清TBA、ALT、AST、TBiL指标水平和异常率及观察组孕妇不同孕周条件下血清TBA水平。结果观察组孕妇血清TBA、ALT、AST水平均高于对照组(P<0.05),且相较于ALT、AST,血清T
2、BA对应的P值最小。观察组孕妇血清TBA、ALT、AST异常率均高于对照组(P<0.05),且相较于ALT、AST,血清TBA对应的P值最小。观察组孕妇血清TBA指标异常率高于ALT、AST异常率(卩〈0.05)。随着妊娠肝内胆汁淤积症孕妇孕期的进展，血清TBA水平逐渐升高(P<0.05)o结论相较于ALT、AST,血清TBA测定诊断ICP的灵敏性和特异性更好,可作为ICP患者常规检测项目之一。［关键词］妊娠肝内胆汁淤积症；血清总胆汁酸；诊断［中图分类号］R714.255［文献标识码］A［文章编
3、号］1674-4721(2014)08(a)-0096-03ClinicalsignificanceanalysisofserumtotalbileaciddetectioninthediagnosisofintrahepaticcholestasisofpregnancyCHENXue-meiHUYong-zhongDepartmentofLaboratory^MaternalandChildHealthHospitalofXinyuCityinJiangxiProvince,Xinyu338
4、025,China[Abstract]ObjectiveToanalyzetheclinicalsignificanceofserumtotalbileacid(TBA)detectioninthediagnosisofintrahepaticcholestasisofpregnancy(ICP)・Methods45casesofpregnantwomenwithICPadmittedandtreatedinourhospitaiwereselectedasobservationgroup.40
5、healthypregnantwomenreceivingphysicalexaminationinthesameperiodwereselectedascontrolgroup.SerumTBA,ALT,ASTandTBiL1evelswastestedforpregnantwomenintwogroupsrespectively.SerumTBA,ALT,ASTandTBiLlevelsandabnormalityratebetweentwogroupswascomparedandanaly
6、sedrespectively.SerumTBAlevelatdifferentgestationalweeksintheobservationgroupwascomparedandanalysed.ResultsTBA,ALTandAST1evelsinobservationgroupwashigherthanthatincontrolgrouprespectively(P<0.05),withthelowestPALTandASTabnormalityratevalueforserumTBA
7、whenthatincontrolgrouprespectively(P<0.05),withthelowestPvalueforserumTBAwhencomparedwithALTandAST.SerumTBA,inobservationgroupwashigherthancomparedwithALTandAST.TBAabnormalityrateinobservationgroupwashigherthanthatALTorASTabnormalityraterespectively(
8、P〈0.05).SerumTBAlevelgraduallyincreasedwithadvanceofgestationinpregnantwomenwithintrahepaticcholestasisofpregnancy(P<0.05)・ConelusionComparedwithALTandAST,serumTBAdetectiondemonstratesbettersensitivityandspecificityinthediagnosisofICP,whichcanbeuseda
