血清总胆汁酸测定诊断妊娠肝内胆汁淤积症的临床意义分析-论文.pdf

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1、·医学检验·中国当代医药2014年8月第21卷第22期血清总胆汁酸测定诊断妊娠肝内胆汁淤积症的临床意义分析陈雪梅胡永忠江西省新余市妇幼保健院检验科。江西新余338025【摘要】目的分析血清总胆汁酸(TBA)~0定诊断妊娠肝内胆汁淤积症(ICP)的临床意义。方法选取本院收治的42例ICP孕妇作为观察组，另选择同期体检的40例健康孕妇为对照组，分别检测两组孕妇的血清TBA、AIJT、AST、TBiL水平，并对比分析两组孕妇血清TBA、ATJT、AST、TBiL指标水平和异常率及观察组孕妇不同孕周条件下血清TBA水平。结果观察组孕妇血清TBA、AIJT、AST水平

2、均高于对照组(P<0．05)，且相较于ALT、AST，血清TBA对应的P值最小。观察组孕妇血清TBA、AIJT、AST异常率均高于对照组(P<0．05)，且相较于ALT、AST，血清TBA对应的P值最小。观察组孕妇血清TBA指标异常率高于AIJT、AST异常率(P

3、号】1674—4721(2014)08(a)一0096—03Clinicalsignificanceanalysisofserumtotalbileaciddetectioninthediag-nosisofintrahepaticcholestasisofpregnancyCHENXue—meiHUYong-zhongDepartmentofLaboratory，MatemalandChildHealthHospitalofXinyuCityinJiangxiProvince，Xinyu338025，China[Abstract]ObjectiveToan

4、alyzetheclinicalsignificanceofserumtotalbileacid(TBA)detectioninthediagnosisofin-trahepaticcholestasisofpregnancy(ICP)．Methods45casesofpregnantwomenwithICPadmittedandtreatedinourhospitalwereselectedasobservationgroup．40healthypregnantwomenreceivingphysicalexaminationinthesamepe—rio

5、dwereselectedascontrolgroup．SerumTBA，ALT，ASTandTBiLlevelswastestedforpregnantwomenintwogroupsrespectively．SerumTBA，A，ASTandTBiLlevelsandabnormalityratebetweentwogroupswascomparedandanal—ysedrespectively．SerumTBAlevelatdifferentgestationalweeksintheobservationgroupwascomparedandanal

6、ysed．ResultsTBA，Al，TandASTlevelsinobservationgroupwashigherthanthatincontrolgrouprespectively(P<0．05)，withthelowestPvalueforserumTBAwhencomparedwithALTandAST．SerumTBA．AIJTandASTabnormalityrateinob—servationgroupwashigherthanthatincontrolgrouprespectively(P<0．05)，withthelowestPvalue

7、forserumTBAwhencomparedwithALTandAST．TBAabnormalityrateinobservationgroupwashigherthanthatALTorASTabnormalityraterespectively(P<0．05)．SerumTBAlevelgraduallyincreasedwithadvanceofgestationinpregnantwomenwithintra—hepaticcholestasisofpregnancy(P<0．05)．ConclusionComparedwithAandAST．se

8、rumTBAdetectiondemonstrate