乌司他丁与奥曲肽联合治疗轻症急性胰腺炎临床研究

《乌司他丁与奥曲肽联合治疗轻症急性胰腺炎临床研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、乌司他丁打奥曲肽联介治疗轻症急性胰腺炎临床研究［摘耍］冃的探讨乌司他丁与奥曲肽联合治疗轻症急性胰腺炎的临床疗效。方法将入组的89例轻症急性胰腺炎患者随机分为观察组(45例)和对照组(44例)。两纽患者均予以常规治疗，包括禁食；胃肠减压，对于腹痛、腹胀、呕吐严重者置胃管持续吸引胃肠减压；经脉输液，积极补充血容量，维持水电解质和酸碱平衡；予以哌替咙止痛；抗生素及抑制胃酸等。対照组在常规治疗基础上加用注射用醋酸奥曲肽；观察组在対照组治疗上应用乌司他丁。两组患者疗程均为5d,评价疗效。结果观察组总有效率为91.11%,对照组总有效率为75.00%,两纟F1总有

2、效率比较差异有统计学意义(P<0.05)o观察纟R患者治疗示血清淀粉酶［(454±87)U/L］、尿淀粉酶［(592土231)U/L］变化与对照组［(520±103)、(766±250)U/L］比较差界均有高度统计学意义(均P<0.01)o结论乌司他丁少奥曲肽联合能够起到协同治疗作川，能显著改善急性轻症胰腺炎患者血清淀粉酶、尿淀粉酚水平，提高临床疗效，值得推广使用。［关键词］轻症急性胰腺炎；奥曲肽；乌司他丁；白细胞介索［中图分类号］R576［文献标识码］A［文章编号］1673-7210(2012)01(b)-091-02Clinicalresearch

3、ofcombinedUlinastatinandOctreotideinthetreatmentofmildacutepancreatitisHUANGQicongDepartmentofGastroerUerology,thePeople'sHospitalofDapuCounty,GuangdongProvince,Dapu514200,China［Abstract］ObjectiveToexploretheclinicalefficacyofcombinedUlinastatinandOctreotideinthetreatmentofmilda

4、cutepancreatitis.Methods89casesofpatientswithmildacutepancreatitiswererandomlydividedintoexperimentgroup(45cases)andcontrolgroup(44cases).Bothofthetwogroupsweregivenbeisictreatment,ineludingambrosia;gastrointestinaldecompressionforpatientswithsevereabdominalpain,abdominaldistens

5、ionandvomitingbyinstallingstomachtubetoobtaincontinuousdrawing;venoustransfusiontoactivelysupplybloodvolumeandmaintainwater-e1ectro1ytebalanceandacid-basebaIaneo;relievingpainwithpethidine;takingantibiotics;inhibitinggastricacidsecretion,andsoon.Octreotideacetateforinjectionwasa

6、ddedtocontrolgrouponthebasisofbasictreatment,andUlinastatinwasaddedtoexperimentgrouponthebasisofcontrolgroup.Thecourseoftreatmentwas5dinbothgroups,thentheclinicalefficacywasassessed.ResultsThetotaleffectiveratewas91.11%inexperimentgroupand75.00%incontrolgroup.Thedifferencesweres

7、ignificant(P<0.05).Thelevelofserumamylase［(454+87)U/L］andurineamylase［(592土231)U/L］inexperimentgroupaftertreatmentweresignificantlydifferentfromthatofcontrolgroup［(520+103),(766±250)U/L］(P<0・01).ConclusionThecombinedtreatmentofUlinastatinandOctreotidecanexpresssyncrgisticeffect,

8、significantlyimprovethelevelofserumamylaseandur