乌司他丁及奥曲肽联合治疗轻症急性胰腺炎临床探究

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1、乌司他丁及奥曲肽联合治疗轻症急性胰腺炎临床探究［摘要］目的探讨乌司他丁与奥曲肽联合治疗轻症急性胰腺炎的临床疗效。方法将入组的89例轻症急性胰腺炎患者随机分为观察组（45例）和对照组（44例）。两组患者均予以常规治疗，包括禁食；胃肠减压，对于腹痛、腹胀、呕吐严重者置胃管持续吸引胃肠减压；经脉输液，积极补充血容量，维持水电解质和酸碱平衡；予以哌替噪止痛；抗生素及抑制胃酸等。对照组在常规治疗基础上加用注射用醋酸肽;II观察组在对照组治疗上应用乌司他丁。两组患者疗程均为5d,评价疗效。结果观察组总有效率为91.11%,对照组总有效率为75.00%,两组总有效率比较差

2、异有统计学意义（P<0.05）o观察组患者治疗后血清淀粉酶［(454±87)U/L］、尿淀粉酶［(592±231)U/L］变化与对照组［（520±103）、（766土250）U/L］比较差异均有髙度统计学意义（均P<0.01）o结论乌司他丁与奥曲肽联合能够起到协同治疗作用，能显著改善急性轻症胰腺炎患者血清淀粉酶、尿淀粉酶水平，提高临床疗效，值得推广使用。［关键词］轻症急性胰腺炎；奥曲肽；乌司他丁；白细胞介素［中图分类号］R576［文献标识码］A［文章编号］1673-7210(2012)01(b)-091-02Clinicalresearchofcombine

3、dUlinastatinandOctreotideinthetreatmentofmildacutepancreatitisHUANGQicongDepartmentofGastroenterology,thePeople'sHospitalofDapuCounty,GuangdongProvince,Dapu514200,China[Abstract]ObjectiveToexploretheclinicalefficacyofcombinedUlinastatinandOctreotideinthetreatmentofmildacutepancreat

4、itis・Methods89casesofpatientswithmildacutepancreatitiswererandomlydividedintoexperimentgroup(45cases)andcontrolgroup(44cases)・Bothofthetwogroupsweregivenbasictreatment,includingambrosia；gastrointestinaldecompressionforpatientswithsevereabdominalpain,abdominaldistensionandvomitingby

5、installingstomachtubetoobtaincontinuousdrawing；venoustransfusiontoactivelysupplybloodvolumeandmaintainwater-electrolytebalanceandacid-basebalance；relievingpainwithpethidine；takingantibiotics；inhibitinggastricacidsecretion,andsoon.Octreotideacetateforinjectionwasaddedtocontrolgroupo

6、nthebasisofbasictreatment,andUlinastatinwasaddedtoexperimentgrouponthebasisofcontrolgroup・Thecourseoftreatmentwas5dinbothgroups,thentheclinicalefficacywasassessed・ResultsThetotaleffectiveratewas91.11%inexperimentgroupand75.00%incontrolgroup.Thedifferencesweresignificant(P<0.05).The

7、levelofserumamylase[(454±87)U/L]andurineamylase[(592±231)U/L]inexperimentgroupaftertreatmentweresignificantlydifferentfromthatofcontrolgroup[(520±103),(766±250)U/L](P<0.01).ConclusionThecombinedtreatmentofUlinastatinandOctreotidecanexpresssynergisticeffect,significantlyimprovethele

8、velofserumamylaseandurinea