资源描述：
《TP方案联合放疗同步与序贯治疗中晚期宫颈癌的对比研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、TP方案联合放疗同步与序贯治疗中晚期宫颈癌的对比研究［摘耍］冃的：探讨中晚期宫颈癌的治疗方法。方法：选取中晚期宫颈癌病例73例，分为同步治疗纟R(37例)和序贯治疗纟R(36例)。同步治疗组放疗开始给予紫杉醇135~175mg/m2,静滴1d；顺钳25~30mg/m2,静滴1〜3d,放疗时间间隔28d重复1次化疗。序贯治疗组给予紫杉醇+顺舘化疗，化疗间歇期行根治性放疗。结果：同步治疗组和序贯治疗组总有效率分别为89.2%(33/37)、69.4%(25/36),两组比较,差异有统计学意义(P<0.05)。两组不良反应发牛率比较，差异无统计学意义(P>0.05)o同步治疗组3年牛存
2、率为78.4%(29/37),序贯治疗纽为55.6%(20/36),3年生存率同步治疗组高于序贯治疗纟R,差异有统计学意义(x2二4.307,IK0.05)。结论：TP方案化疗联合放疗同步治疗中晚期宫颈癌的疗效高于序贯治疗组，值得在临床推广应用。［关键词］屮晚期宫颈癌；化疗；放疗；紫杉醇；顺钳［中图分类号］R737.33［文献标识码］A［文章编号］1673-7210(2011)11(a)-050-02ContraststudyonTPcombinedwithradiotherapyconcurrentandsequentialtherapyintreatmentofadvance
3、dcervicalcancerKANGTing,LIUMin,ZHANGLuDepartmentofOncology,AffiliatedHospitalofYan'anUniversityinShaanxiProvince,Yan'an716000,China［Abstract］Objective:Toexplorethemethodinthetreatmentofadvaneedcervicalcancer.Methods:73advancedcervicalpatientswererandomlydividedintotwogroups:concurrenttherapyg
4、roup(37cases)andsequentialtherapygroup(36cases).ConcurrenttherapygroupwastreatedbyPTX,135-175mg/m2,ivgtt,1d;DDP25-30mg/m2,ivgtt,1-3d,every28daysafterradiotherapyrepeatedchemotherapyonce;SequentialtherapygroupwastreatedbyPTX+DDPchemotherapy,inintermissionofchemotherapywasgivenradiotherapy.Resu
5、lts:Thetotaleffectiverateoftheconcurrenttherapygroupandthesequentialtherapygroupwere89・2%(33/37)and69.4%(25/36)respectively,therewasasignificantdiffereneobetweenthem(P〈0・05);Therewasnosignificantdifferenceofadversereaction(ADR)ratesbetweenthetwogroups(P>0・05);3yearsurvivalrateoftheconcurrentt
6、herapygroupwas78.4%(29/37),itwasmorebetterthatofsequentialtherapygroup［55.6%(20/36)］,therewasasignificantdifferencebetweenthem(x2=4.307,P<0.05)-Conclusion:TPcombinedwithradiotherapyconcurrentintreatmentcervicalcancerisbetterthansequentialtherapygroup,anditiswe11worthyofclinicalpopularizingand
7、application.［Keywords］Advaneedcervicalcancer;Chemotherapy;Radiotherapy;PTX;DDP宫颈癌是导致女性因癌症死广的笫二大原因。每年新诊断的病例超过500000例，死广率约为50%o严重威胁着广大妇女的生命。其治疗早期以根治性手术为主，晚期则以放射治疗为主。因为有天然的腔道，使示装治疗加体外照射的放疗模式成为经典的治疗模式，明显提高了放疗的疗效。但小晩期宫颈癌的预后较差，近年來，放化疗联合治疗成为治疗屮晚期宫颈癌
