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1、新生儿败血症60例临床分析何柳虎春元李娟王贞美【摘要】目的探讨近年来我院新牛儿病房收治的新牛儿败血症的临床表现，病原菌分布及药敏特点，以指导临床治疗。方法：回顾性分析木院新生儿病房2011年5月至2013年5月经血培养确诊为新牛儿败血症的60例患儿的资料。结果新牛儿败血症临床表现缺乏特异性，以少吃、少动、少哭，体温波动、黄疸等表现为主。研究期间共检出病原菌60株，其中革兰氏阳性菌60%,革兰氏阴性菌40%,排在前5位分别是衣皮葡萄球菌，大肠埃希菌，溶血性窗萄球菌，肺炎克雷伯菌，阴沟肠杆菌。革兰氏阳性菌对
2、青霉素、苯醴西林、红霉素耐药率高，对万右霉素、利福平尚未耐药；但部分溶血性葡萄球菌对青霍索、苯畔西林敏感。革兰氏阴性菌对氨节西林、头抱类、氨曲南耐药性高，対哌拉西林他哇巴坦、碳青霉烯类尚未耐药•，但阴沟肠杆菌対头他三代以上仍敏感性高。结论根据病原菌及其耐药性检测选用敏感药物治疗新生儿败血症，可减少耐药菌株的产生，提高治疗效果。【关键词】败血症；病原菌；药敏试验；婴儿，新生儿Clinicalanalysisof60casesofneonatalsepticemiaHELiu,HUChunyuan,LIJu
3、an,WANGZhen・mei・DepartmentofNeonatology,BazhongCentralHospitalofSichuanProvince,bazhong636000,China[Abstract]ObjectiveToinvestigateThedistributionofpathogenicbacteriaax!dru(:esislaneeciacmrisicsofneonatalsepticemiainneonatalwardofourhospitalinrecentyears
4、,toguidetheclinicaltreatment.MethodsRetrospectivelyanalysiswasperformedontheclinicaldataof60neonateswithsepticemiahospitalizedfrom2011Mayto2013May.ResultsTheclinicalmanifestationsofneonatalsepticemialackofspecificity,withfever,jaundice,eatless,reactionan
5、dpoorperformance.Duringthestudyperiod,therewere60strainsofpathogenicbacteriajncluding60%grampositivebacteria,40%gramnegativebacteriaJnthetop5wereStaphylococcusaureus,Escherichiacoli,Staphylococcushaemolyticus,Klebsiellapneumoniae,Enterobactercloacae..Esc
6、eptPartofStaphylococcushaemolyticusissensitivetothepenicillinandoxacillin,otherGrampositivebacteriahavehighdurg-resistantonthepenicillin,oxacillin,erythromycin,butnosuchresistantwasobservedforrifampicin,vancomycin.EsceptPartofEnterobactercloacaeissensiti
7、vetothecefotaximesodium,ceftazidime5otherGramnegativebacteriahavehighdurg-resistantontheampicillin,cephalosporin，aztreonam,butnosuchresistantwasobservedforTazobactamSodium/PiperacillinSodiumforlnjectio,carbopenems・ConclusionaccordingtoThedetectionofpatho
8、genicbacteriaandtheirdrugresistaneetoselectsensitivedrugsinthetreatmentofneonatalsepticemia,whichcanreducetheemergenceofresistantstrains,improvethetherapeuticeffect.[Keywords]Septicemia,Pathogen，Drugsensitivitytest,Infant,
