卡维地洛对大鼠心肌梗塞后左室功能及胶原改建的影响（医学论文）

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1、卡维地洛对大鼠心肌梗塞后左室功能及胶原改建的影响作者：张军，贾国良，王海昌，张荣庆【关键词】心肌梗塞[Abstract]AIM：Toobservetheeffectsofcarvedilolinjectionontheleftventricularfunctionandcollagenremodelingofnon-infarctedareaaftermyocardialinfarction.METHODS:SixshamoperatedSDratsservedascontrols(sham).Fiftyratswithamodelofmyocardialinfarctionwererando

2、mlydividedintoninegroups・Theratsweretreatedwithcarvedilolinjection(2mg・d—1intraperitonealinjection)and/orcaptopril(2g・L—1drinkingwater).Acutemyocardialinfarction(AMI)groupdidnotreceiveanydrugtreatment.Theanimalsweresacrificed4weeksor8weeksaftercoronaryarteryligation.Thelevelsofplasmaan

3、giotensinIIandplasmaaldosterone(byRIA)andleftventriclefunction(bycathetermeasuring)werestudiedatdifferenttimes・Thecollagencontent(hydroxyprolinelevels)andtheratiooftypeIandIDcollagen(byimmunohistochemicalstaining)ofnoninfarctedareawerealsoassessedinallratsatthefourthortheeighthweek・RESULTS:Comparedw

4、iththoseoftheAMIgroup,bothcarvedilolandcaptoprildecreasedthelevelsofplasmaandmyocardiumangiotensinIIandplasmaaldosteroneattheeighthweek(P&It;005)andcarvedilolimprovedsystolicanddiastolicfunction(P<005).Comparedwiththoseoftheshamgroup,bothcollagencontent(hydroxyprolinelevels)andtheratiooftypeI/DIc

5、ollagenofnoninfarctedarea(includingtheinfarctborder)increasedinAMI4andAMI8group(P<0.05).ThehydroxyprolinelevelsandtheratiooftypeI/HIcollagensignificantlydecreasedaftercarvediloland/orcaptopriltreatmentcomparedwiththoseoftheAMIgroupatthefourthortheeighthweek(P<0.05)・CONCLUSION:Carvedilolcanimpr

6、ovethecardiacfunctionaftermyocardialinfarctionandhasbeneficialeffectsontheleftventricularcollagenremodeling・[Keywords]carvedilol;myocardialinfarction;collagen;ventricularfunction,left【摘要】目的：在实验性大鼠心肌梗死模型上观察卡维地洛对心梗后左室功能及胶原改建的影响•方法：心梗后腹腔注射卡维地洛注射液4wk或8wk,用放免法测定血浆、心肌血管紧张素n(AngH)^血浆醛固酮(ALD),动脉插管测定大鼠心功能，氯胺

7、T法测定非梗塞区左室心肌轻脯氨酸含量，免疫组织化学法测定I型胶原和皿型胶原含量的变化•结果：与心肌梗死对照组相比，卡维地洛可降低8wk时的血浆、非梗死区心肌Angn及血浆ALD水平(P<005);治疗4wk和8wk后可明显升高+dp/dtmax及dp/dtmax水平(P<005),减少非梗死区左室心肌轻脯氨酸的含量;降低非梗死区心肌I型胶原和皿型胶原蛋白比值(P<O・O5)・结论