卡维地洛对多柔比星诱导心肌病大鼠氧化应激的影响

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1、卡维地洛对多柔比星诱导心肌病大鼠氧化应激的影响作者：俞捷，王成华，陶艾彬，尹春阳，汪建飞，张国辉【摘要】目的：探讨卡维地洛(carvedilol,CVD)对多柔比星(adriamycin,ADR)致心肌病大鼠氧化应激水平的影响及其可能机制。方法：采用腹腔注射多柔比星建立心肌病大鼠模型,随机分为卡维地洛组和多柔比星组，每组10只。另取正常大鼠10只为正常对照组。卡维地洛组每日给予卡维地洛60mg/kg；多柔比星组、正常对照组每日给予相同体积生理盐水，观察8周。第9周行心脏超声和血流动力学检测，测定心室胶原含量，总抗氧化能力和丙二醛浓度。结

2、果：卡维地洛组与多柔比星组相比，可显著提高左室射血分数(P<0.01)；降低心肌胶原容积分数(P<0.01)。与正常对照组相比，多柔比星组总抗氧化能力显著降低(P<0.01)，丙二醛浓度显著升高(P<0.01)；而与多柔比星组相比，卡维地洛组可显著提升总抗氧化能力(P<0.01)，明显降低丙二醛浓度(P<0.05)。结论：卡维地洛能显著改善多柔比星引起的血流动力异常，改善心脏收缩与舒张功能，逆转心肌重塑，可能与其提高心肌抗氧化应激能力有关。【关键词】多柔比星；卡维地洛；氧化应激　　［Abstract］

3、Objective:Toinvestigatetheinfluenceof14oxygenstressinratwithadriamycininducedcardiomyopathy,andtointervenewiththethirdgenerationblocker:carvediloltoexploreitspossiblemechanism.Methods：MaleSpragueDawleyratswereadministeredadriamycinintraperitoneallyinjected.Randomlydiv

4、idedintotwogroups(n=10ineachgroup):carvedilolgroup(60mg/kgdaily),adriamycingroupandanothernormalheartcontrolgroup(givinganequivalentvolumeof0.9%salinedaily).After8weeksofremedy,echocardiography,hemodynamicparameters,thevolumetricfractionofcollagenousfibre(CVF)andoxidativ

5、estressincludingtotalantioxidationcapacity(TAOC)andmalondialdehyde(MDA)werestudied.Results：Comparedwithadriamycingroup,carvedilolgroupcansignificantlyimproveleftventricularejectionfraction(P<0.01)anddepressCVFobviously(P<0.01).Comparedwithcontrolgroup,adriamycingr

6、oupcansignificantlydecreasetheactivityofTAOC(P<0.01)andimprovethecontentsofMDAgreatly(P<0.01).TheactivityofTAOCinthecarvedilolgroupwasenhancedsignificantlycomparedwiththatintheadriamycingroup(P<0.01).ThecontentsofMDAinthecarvedilolgroupweredecreasedcomparedwit

7、hthatintheadriamycingroup(P<0.05).Conclusion：Carvedilolcanrelieveadriamycininducedhemodynamicabnormality14evidently,improvecardiacsystolicanddiastolicfunctiongreatlyandreverseventricularremodeling.Thismechanismmaybeconcernedwithitsimprovementtooxygenstress.　　［Keyword

8、s］adriamycin;carvedilol;oxidativestress　　多柔比星(adriamycin,ADR)作为一种有效的蒽环类广谱抗癌药物,被广泛应用于治疗多种恶性肿瘤。然而,其具有严重的心