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1、临床肿瘤学杂志2007年12月第12卷第12期ChineseClinicalOncology,Dec.2007,Vo.l12,No.12919113例原发性肝癌的临床病理分析210002南京解放军八一医院病理科乐美兆,张佃乾,殷正进,李祥周摘要目的:探讨原发性肝癌临床及病理学特征。方法:对113例原发性肝癌的临床资料和病理资料进行回顾性分析。结果:113例原发性肝癌有91例为肝细胞癌,22例为胆管癌。91例肝细胞癌患者均为乙肝患者,其中86例伴发结节性肝硬化,87例AFP阳性;组织学类型小梁型56例,假腺型15例,实体型20例。22例胆管癌患者
2、仅1例有乙肝病史,3例合并肝血吸虫病,5例合并胆管炎症或结石。结论:肝细胞癌与乙肝病毒感染密切相关,常见于结节性肝硬化患者,大部分患者AFP阳性,组织学类型以小梁型为主。胆管癌多见于女性,通常无肝硬化,与血吸虫感染或胆管炎症有较密切关系。关键词原发性肝癌;肝细胞癌;胆管癌;临床病理分析中图分类号:R735.7文献标识码:A文章编号:1009-0460(2007)12-0919-04Clinicopathologicanalysisofthe113casesofprimarylivercarcinomasLEMei-zhao,ZHANGDian
3、-qian,YINZheng-jin,LIXiang-zhou.DepartmentofPathology,81HospitalofPLA,Nanjing210002,ChinaAbstractObjective:Toexploreclinicalandpathologicfeatureofprimarylivercarcinoma.Methods:Clinicopathologicdateofthe113casesofprimarylivercarcinomawereanalysed.Results:Amongthe113casesofprimarylive
4、rcarcinoma,91casesbelongedtohepatocellularcarcinoma(HCC),and22caseswerecholangiocarcinoma(ICC).allpatientsofHCChadbeenfoundtobeassocia-tedwithhepatitisB,86ofthe91casesoftheHCCwerefoundtodevelopnodularlivercirrhosis,positivityforAFPwasfoundin87ca-ses,ThreetypicalhitologicpatternsofHCChave
5、beenfound,includingtrabecularpatternin56cases,pseudoglandulartypein15ca-ses,andsolidpatternin20cases.Amongthe22casesoftheICC,onlyonewasfoundtobeapatientwithchronichepatitisB.Incon-trasttoHCC,3caseswasassociatedwithcholangifisorcholelithiasis.Conclusion:TheHCCwasusuallyseeninthesettingofc
6、irrhosisandcloselyrelatedtoinfectionwithHBV,ahightserumAFPlevelwereseeninthemajorityofpatients,themostcommonhistologicpatternswerethetrabecularpattern.TheICCusuallyoccursinmorefemalesthanmale,ingenera,lnoassociationwithcirrhosishavebeennoted,butrelatedtocholangitisorcholelithiasis,aswith
7、parasiticinfectiontheliver.KeyWordsPrimarylivercarcinoma;Hepatocellularcarcinoma;Cholangiocarcinoma;Clinicopathologicanalysis原发性肝癌为肝脏恶性上皮性肿瘤,约占所有癌局部肝叶切除标本以及肝肿块穿刺活检组织。所原发性肝脏肿瘤的98%,其中肝细胞癌是最常见获组织均经10%福尔马林固定,常规石蜡包埋,HE[1](85%~90%)的组织学类型。我国是肝细胞癌染色。高发区,约占癌症死亡的20%~40%,其
