History of Research on Tumor Angiogenesis

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1、HistoryofResearchonTumorAngiogenesisDomenicoRibattiHistoryofResearchonTumorAngiogenesis123Prof.DomenicoRibattiUniversitadiBari`PoliclinicoDipartimentodiAnatomiaUmanaeIstologiaBariItalyribatti@anatomia.uniba.itISBN978-1-4020-9559-7e-ISBN978-1-4020-9563-4DOI10.1007/978-1

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4、orangiogenesisContentsChapter1.........................................................11.1EarlyEvidenceoftheVascularPhaseandItsImportanceinTumorGrowth..........................................11.2EarlyEvidenceofTumorCellsReleasingSpecificGrowthFactorforBloodVessels....

5、.....................................21.3TumorsinIsolatedPerfusedOrgans:AbsenceofAngiogenesis...51.3.1Hypothesis:TumorGrowthIsAngiogenesis-Dependent..61.3.2EvidencethatTumorsAreAngiogenesis-Dependent.....61.4TheAvascularandVascularPhasesofSolidTumorGrowth......91.4.1Fi

6、rstEvidenceoftheExistenceoftheAvascularandVascularPhasesofSolidTumorGrowth..............91.4.2TheSignificanceofAngiogenesisinHematologicalMalignancies.....................................101.4.3Non-Angiogenesis-DependentPathwaysforTumorGrowth:VascularCooptionandVasculog

7、enicMimicry..15Chapter2.........................................................192.1IsolationoftheFirstAngiogenicTumorFactor.................192.2TheDiscoveryofBasicFibroblastGrowthFactor/FibroblastGrowthFactor-2..........................................202.2.1FGF-2Re

8、ceptorsandFGF-2Interactions..............212.2.2TheRoleofFGF-2inTumorGrowthandVascularization222.3TheDiscoveryofVascu