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1、Thea-GlucosidaseIInhibitorCastanospermineAltersEndothelialCellGlycosylation,PreventsAngiogenesis,andInhibitsTumorGrowthRobertoPili,JoanChang,RichardA.Partis,etal.CancerRes1995;55:2920-2926.UpdatedVersionAccessthemostrecentversionofthisarticleat:http://can
2、cerres.aacrjournals.org/content/55/13/2920CitingArticlesThisarticlehasbeencitedby10HighWire-hostedarticles.Accessthearticlesat:http://cancerres.aacrjournals.org/content/55/13/2920#related-urlsE-mailalertsSignuptoreceivefreeemail-alertsrelatedtothisarticle
3、orjournal.ReprintsandToorderreprintsofthisarticleortosubscribetothejournal,contacttheAACRPublicationsSubscriptionsDepartmentatpubs@aacr.org.PermissionsTorequestpermissiontore-useallorpartofthisarticle,contacttheAACRPublicationsDepartmentatpermissions@aacr
4、.org.Downloadedfromcancerres.aacrjournals.orgonJanuary27,2013Copyright©1995AmericanAssociationforCancerResearch[CANCERRESEARCH55,2920—2926,July1,1995]Thea-GlucosidaseIInhibitorCastanospermineAltersEndothelialCellGlycosylation,PreventsAngiogenesis,andInh
5、ibitsTumorGrowthRobertoPili,JoanChang,RichardA.Partis,RichardA.Mueller,FrancisJ.Chrest,andAntomnoPassaniti'CellBiologyUnit,LaboratoryofBiologicalChemistry[R.P.,.1.C.,A.P.],andClinicalImmunologySection,LaboratoryofClinicalPhysiology[F.J.C.).GerontologyRese
6、archCenter,NationalInstituteonAging,NIH.Baltimore.Maryland21224.andSearleResearchandDevelopment,Skokie.Illinois60077[R.A.P.,R.A.M.)ABSTRACTFurthermore,CSTandN-MDJNhavebeenshowntoinhibitcellulartransformationbyalteringoncogeneglycosylation(12).Thedevelopme
7、ntofdrugsthattargetthetumorneovasculaturemayAngiogenesis,theformationofnewcapillaries,isessentialduringholdpromiseininhibitingtumorgrowth.Experimentsinvivowithensembryonicdevelopment,endometrialcycling,andwoundhealing.tanospermine,aninhibitoroftheglucosid
8、asesthatconvertproteinN-Increasedangiogenesisisobservedinmanypathologicalconditionslinkedhighmannosecarbohydratestocomplexoligosaccharides,resultedinsignificantinhibitionoftumorgrowthinnudemice.Angiogenesistoincludi
