Histologic and molecular characterization of lung cancer with tissue obtained by electromagnetic navigation bronchoscopy

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1、ORIGINALINVESTIGATIONHistologicandMolecularCharacterizationofLungCancerWithTissueObtainedbyElectromagneticNavigationBronchoscopyDucHa,MD,*HumbertoChoi,MD,wFranciscoA.Almeida,MD,MS,wAndreaArrossi,MD,zJenniferBrainard,MD,zJosephCicenia,MD,wCarolFarver,MD,zTho

2、masGildea,MD,MS,wMichaelS.Machuzak,MD,wandPeterMazzone,MD,MPHwConclusions:ENBiseffectiveatobtainingtissuesam-Background:Electromagneticnavigationbronchoscopyplesadequateforhistologicsubtyping,EGFRmuta-(ENB)isacatheter-basedadjuncttostandardbron-tion,andEML4-

3、ALKtranslocationanalysis.choscopictechniquesforthesamplingoflunglesions.WesoughttoevaluatetheadequacyofENB-obtainedKeyWords:electromagneticnavigationbronchoscopy,lungcancer,histology,immunohistochemistry,epidermalsamplesforhistologicsubtypingoflungcancer,ep

4、i-growthfactorreceptor(EGFR)mutation,echinodermdermalgrowthfactorreceptor(EGFR)mutations,andmicrotubule-associatedprotein-like4-anaplasticlymphomaechinodermmicrotubule-associatedprotein-like4-ana-kinase(EML4-ALK)translocationplasticlymphomakinase(EML4-ALK)t

5、ranslocations.(JBroncholInterventPulmonol2013;20:10–15)Methods:WeretrospectivelyanalyzedconsecutivepatientswhounderwentENBforthediagnosisoflunglesionsbetween2008and2011.InthoseproventobeaistologicsubtypingplaysanimportantroleprimarylungcancerbyENB,tissueade

6、quacyforhis-tologicsubtypingwasrecorded.Accuracywasdeter-Hindecidingthecourseoftreatmentforminedbycomparisonwithresectedspecimenswhenpatientsdiagnosedwithlungcancer.1Previousavailable.TissueadequacyforEGFRmutationand/orstudieshaveshownthatpatientsresponddiff

7、er-EML4-ALKanalyseswasalsoreviewed.entlytochemotherapyandtargetedtherapyResults:Sixty-fiveENBcasesresultedinadiagnosisofdependingonthehistologicsubtypesoftheirlungcancer.Tissuesobtainedwereadequateforhis-lungcancer.2,3Forinstance,patientswithtologicsubtyping

8、inall65cases.Forty-three(66.2%)stage4nonsquamousnon-smallcelllungcancerwerediagnosedwithadenocarcinoma,19(29.2%)with(NSCLC)haveimprovedsurvivalandlesstox-squamouscellcarcinoma,3(4.6%)withsmallcellicity