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1、NEURALREGENERATIONRESEARCHVolume7,Issue18,June2012www.nrronline.orgCitethisarticleas:NeuralRegenRes.2012;7(18):1428-1435.Five-yearfollow-upof23asymmetricalParkinson’sdiseasepatientstreatedwithunilateralsubthalamicnucleusstimulation*★111111JinchuanLiang,XiaowuHu,XiaopingZhou,XiufengJiang,YiqunCao,La
2、ixingWang,21AiguoJin,JianminLiu1DepartmentofNeurosurgery,ChanghaiHospitaloftheSecondMilitaryMedicalUniversityofChinesePLA,Shanghai200433,China2DepartmentofRadiology,ChanghaiHospitaloftheSecondMilitaryMedicalUniversityofChinesePLA,Shanghai200433,ChinaAbstractInthisstudy,23asymmetricalParkinson’sdise
3、asepatientsweretreatedwithunilateraldeepbrainJinchuanLiang★,Master,Physician,Departmentofstimulationofthesubthalamicnucleusandfollowedupfor5years.At5yearsafterstimulationNeurosurgery,Changhaitreatment,UnifiedParkinson’sDiseaseRatingScaleII,IIIandaxialsymptomscoresintheoff-drugHospitaloftheSecondcon
4、ditionweresignificantlyincreasedcomparedthoseatbaseline.However,totalUnifiedMilitaryMedicalUniversityofChinesePLA,ShanghaiParkinson’sDiseaseRatingScaleII,IIIandaxialsymptomscoresweresignificantlylowerwith200433,Chinastimulation-oncomparedwiththesynchronousstimulation-offstateinoff-drugcondition,and
5、themotorsymptomsofcontralateralsidelimbswereeffectivelycontrolled.OnlylowHoehn-YahrstageCorrespondingauthor:XiaowuHu,Master,wascorrelatedwithgoodlong-termpostoperativeimprovementinmotorsymptoms.ThemeanProfessor,Departmentoflevodopa-equivalentdailydoseafterstimulationtreatmentwassignificantlylowerth
6、anthatbeforeNeurosurgery,Changhaitreatment,butdyskinesiasbecameworse.OurexperimentalfindingsindicatethatunilateraldeepHospitaloftheSecondMilitaryMedicalUniversityofbrainstimulationofthesubthalamicnucleusisaneffectivetreatmentforimprovingmotorsymptomsChinesePLA,ShanghaiinwellselectedasymmetricalPark
7、inson’sdiseasepatientspresentingnosevereaxialsymptoms200433,Chinaanddyskinesias.huxiaowu25@sina.comReceived:2012-01-08KeyWordsAccepted:2012-04-23Parkinson’sdisease;deepbrainstimulation;subthalamicnucleus;ne
