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1、中国组织工程研究第16卷第3期2012–01–15出版ChineseJournalofTissueEngineeringResearchJanuary15,2012Vol.16,No.3聚乳酸/聚乙二醇琥珀酸酯-姜黄素纳米粒的制备及体外评价*★潘艺茗，黄岳山Preparationandinvitroevaluationofpoly(lactide)/tocopherylpolyethyleneglycolsuccinate-curcuminnanoparticlesPanYi-ming,HuangYue-shanAbstractBACKGROUND:Poly(lactide)(P
2、LA)anditscopolymerareaclassofbiodegradablepolymermaterialswithgoodbiocompatibility,Departmentofwhichhavebeenwidelyusedforbiodegradablesustainedreleasedrugsortargeteddrugdeliverysystems.BiomedicalEngineering,SouthOBJECTIVE:Toexplorethepreparationmethodofthedrug-loadednanoparticlesonentrapmentr
3、ates(ER)anddrugloadingChinaUniversityof(DL)efficiency,andtodeterminetheoptimalpreparationconditionsusingtocopherylpolyethyleneglycolsuccinate(TPGS)asTechnology,emulsifier,curcuminasamodeldrugandPLAascarriers.GuangzhouMETHODS:CurcuminloadedPLAnanoparticles(NPs)werepreparedbyanO/Wemulsion-solve
4、ntevaporationmethod.TheER510006,GuangdongProvince,ChinaandDLwereusedasthemainguiders.SingefactortestwasusedinordertofindtheeffectofallkindsofparametersontheNP’spreparation,andthenNP’sformulationswereoptimizedbyorthogonaldesigntest.PanYi-ming★,RESULTSANDCONCLUSION:Theoptimalpreparationconditio
5、nsofNPsweredeterminedthroughorthogonalexperiment.Studyingformaster’sTheoptimaltechniqueparameterswerefollowed:watertoorganicratioof10:1,polymerconcentrationof15g/L,drugdegree,DepartmentofBiomedicalconcentrationof3g/L,emulsifierTPGSconcentrationof0.03%.NPspreparedundertheoptimumconditionweresp
6、hericalandEngineering,Southsmoothwithnarrowparticlesizedistributionandsustaineddrugrelease.Themeandiameterwas167.5nm,theERwas89.52%,ChinaUniversityofandtheDLwas13.72%.Thispreparationprocessisstable,simpleandfeasible,andtheNPswithahighlyER,DL,anduniformTechnology,sizedistributioncanbepreparedu
7、nderoptimalpreparationconditions.Guangzhou510006,GuangdongProvince,ChinaPanYM,HuangYS.Preparationandinvitroevaluationofpoly(lactide)/tocopherylpolyethyleneglycolsuccinate-curcuminpym200888@nanoparticles.ZhongguoZuzhiGongchengYanjiu.2012;16(3)
