欢迎来到天天文库
浏览记录
ID:36464193
大小:792.32 KB
页数:42页
时间:2019-05-10
《上海地区汉族人群维生素D受体基因多态性与1型糖尿病的相关性研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、上海交通大学硕士学位论文上海地区汉族人群维生素D受体基因多态性与1型糖尿病的相关性研究姓名:张薇薇申请学位级别:硕士专业:内科学(内分泌)指导教师:盛正妍20070501上海交通大学硕士学位论文餐后1h和餐后2h)值之间无统计学差异(F值分别为0.098,0.416,0.701,P值分别为0.907,0.666,0.509)。(4)GAD65抗体(+)的1型糖尿病患者与正常对照者相比,FoKΙ位2点基因型和F/f等位基因分布有统计学差异(X值分别为8.905,8.758,P值分别为0.012,0.003);GA
2、D65抗体(-)1型糖尿病患者与正常对照者2相比,FoKΙ位点基因型和F/f等位基因分布无统计学差异(X值分别为2.077,1.192,P值分别为0.354,0.275)。结论:VDR-FoKΙ可能是上海地区汉族人群1型糖尿病的易感基因。VDR-FoKΙ位点基因多态性也可能与GAD65抗体(+)的1型糖尿病相关。本课题探讨了1型糖尿病的遗传机制,证明其发病与VDR基因有关,在分子水平阐明1型糖尿病的发病机制。关键词:1型糖尿病,VDR基因,基因多态性,聚合酶链反应上海交通大学硕士学位论文THEASSOCIATI
3、ONOFVITAMINDRECEPTORGENEPOLYMORPHISMWITHTYPE1DIABETESMELLITUSINTHEHANNATIONALITYOFSHANGHAIAREAABSTRACTOBJECTIVE:ToinvestigatetheassociationofvitaminDreceptor(VDR)genepolymorphismwithtype1diabetesmellitusinpatientsofHannationalityinShanghaiarea.METHODS:80DM1p
4、atientsand80normalsubjectsascontrolwereinvolvedinthisstudy.TheVDR-FoKΙgenotypeswereevaluatedbypolymerasechainreactionfragmentlengthpolymorphism(PCR-RFLP).ThecomparisonsweremadeofrespectivegenefrequenciesandallelefrequenciesbetweenDM1patientsandnormalcontrols
5、.WestudiedtheassociationofgenefrequenciesandserumCpeptidelevels.WealsoinvestigatedassociationsbetweenVDRgenepolymorphismsandGAD65antibodypositivity.RESULTS:(1)Castle-Hardy-WeinbergequilibriumwasevidentforVDR-FoKΙgenepolymorphism.(2)TheprevalenceoftheFallele/
6、theFFgenotypewashigherinthepatientsthanthatinnormalcontrols(P=0.007and0.022,respectively).(3)TheCpeptide(fasting,1hrand2hr)indifferentgenotypeofVDR-FoKΙwithDM1wassimilar.上海交通大学硕士学位论文(4)GenotypeandallelefrequenciesdifferedsignificantlybetweenGAD65antibodyposi
7、tivepatientsandcontrols(P=0.012and0.003,respectively),butneitherbetweenGAD65antibodynegativepatientsandcontrols(P=0.354and0.275,respectively).CONCLUSION:TheVDR-FoKΙgenotypesmaybeusedasgeneticmarkersinpredictingtheirriskofdevelopingDM1intheHannationalityinSha
8、nghaiarea.KEYWORDS:type1diabetesmellitus,vitaminDreceptorgene,polymorphism,polymerasechainreaction上海交通大学硕士学位论文符号说明PCRpolymerasechainreaction多聚酶链反应RFLPrestrictionfragmentlengthpolymorphism限制性酶切片段
此文档下载收益归作者所有