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1、NameofJournal:WorldJournalofGastroenterologyESPSManuscriptNO:31402ManuscriptType:REVIEWTraditionalChineseherbalextractsinducingautophagyasanovelapproachintherapyofnonalcoholicfattyliverdiseaseLiuCetal.AutophagybytraditionalChineseherbalextractsinNAFLDCongLiu,Jia-ZhiLiao,Pei-
2、YuanLiCongLiu,Jia-ZhiLiao,Pei-YuanLi,DivisionofGastroenterology,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,HubeiProvince,ChinaAuthorcontributions:LiuCwrotethemanuscript;LiaoJZandLiPYreviewedthemanuscript.SupportedbyNationalNatura
3、lScienceFoundationofChina,No.81372663andNo.81672392.Conflict-of-intereststatement:Theauthorsdeclarenoconflictofinterestsforthisarticle.Open-Access:Thisarticleisanopen-access article whichwasselectedbyanin-houseeditorandfullypeer-reviewedbyexternalreviewers.Itisdistributedina
4、ccordance withtheCreativeCommonsAttributionNonCommercial(CCBY-NC4.0)license,whichpermitsotherstodistribute,remix,adapt,builduponthisworknon-commercially,andlicensetheirderivativeworksondifferentterms,providedtheoriginalworkisproperlycitedandtheuseisnon-commercial.See:http://
5、creativecommons.org/licenses/by-nc/4.0/Manuscript source:Unsolicited manuscriptCorrespondenceto:Dr.Pei-YuanLi,AssociateProfessor,DivisionofGastroenterology,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,1095JiefangAve,Wuhan430030,HubeiProvince,C
6、hina.pyli@tjh.tjmu.edu.cnTelephone:+86-27-83663661Fax:+86-27-83663661Received:November14,2016Peer-reviewstarted:November17,2016Firstdecision:December2,2016Revised:December23,2016Accepted:January18,2017Articleinpress:Publishedonline:AbstractNon-alcoholicfattyliverdisease(NAFL
7、D)isoneoftheleadingcausesofchronicliverdiseasesaroundtheworldduetothemodernsedentaryandfood-abundantlifestyle,whichischaracterizedbyexcessivefataccumulationintheliverrelatedwithcausesotherthanalcoholabuse.Itiswidelyacknowledgedthatinsulinresistance,dysfunctionallipidmetaboli
8、sm,endoplasmicreticulumstress,oxidativestress,inflammation,apoptosis/necros
