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1、CellularSignalling21(2009)1356–1360ContentslistsavailableatScienceDirectCellularSignallingjournalhomepage:www.elsevier.com/locate/cellsigReviewSIRT1:Regulationoflongevityviaautophagya,b,⁎,KaiKaarnirantac,dAnteroSalminenaDepartmentofNeurology,InstituteofClinicalMedicine,UniversityofKuopio,P.O.
2、Box1627,KuopioFIN-70211,FinlandbDepartmentofNeurology,UniversityHospitalofKuopio,P.O.Box1777,FIN-70211Kuopio,FinlandcDepartmentofOphthalmology,InstituteofClinicalMedicine,UniversityofKuopio,P.O.Box1627,FIN-70211Kuopio,FinlanddDepartmentofOphthalmology,UniversityHospitalofKuopio,P.O.Box1777,FI
3、N-70211Kuopio,FinlandarticleinfoabstractArticlehistory:RecentstudieshaveemphasizedtheimportanceofSIRT1,amammalianhomologofSir2longevityfactor,inReceived15January2009theregulationofmetabolism,cellularsurvival,andorganismallifespan.ThesignalingnetworkinteractingAccepted17February2009withSIRT1co
4、ntinuestoexpandasdoesthenumberoffunctionsknowntoberegulatedbySIRT1.AutophagyAvailableonline26February2009isalsoanemergingfieldinlongevitystudies.Autophagocytosisisahousekeepingmechanismcleaningcellsfromaberrantanddysfunctionalmoleculesandorganelles.TheextensionoflifespanhasbeenlinkedtotheKeywo
5、rds:efficientmaintenanceofautophagicdegradation,aprocesswhichdeclinesduringaging.Interestingly,recentAgingCaloricrestrictionobservationshavedemonstratedthatSIRT1regulatestheformationofautophagicvacuoles,eitherdirectlyorLysosomesindirectlythroughadownstreamsignalingnetwork.Wewillexaminethesigna
6、lingpathwayslinkingSIRT1p53totheregulationofautophagicdegradation.TheinteractionsofSIRT1withtheFoxOandp53signalingcanSir2alsoregulateboththeautophagicdegradationandlifespanextensionemphasizingthekeyroleofautophagySirtuinsintheregulationoflifespan.©2009ElsevierInc.Allrightsreserved.Contents1.I
7、ntroduction.......................................................13562.SIRT1deacetylase:keyregulatorofmetabolismandcellsurvival.................................13573.SIRT1andlifespanextension................................................13
