Effects of FOXO Genotypes on Longevity.pdf

Effects of FOXO Genotypes on Longevity.pdf

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时间:2019-02-28

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1、JournalofGerontology:BIOLOGICALSCIENCES©TheAuthor2010.PublishedbyOxfordUniversityPressonbehalfofTheGerontologicalSocietyofAmerica.Citejournalas:JGerontolABiolSciMedSci.2010December;65A(12):1285–1299Allrightsreserved.Forpermissions,pleasee-mail:journals.permiss

2、ions@oxfordjournals.org.doi:10.1093/gerona/glq156AdvanceAccesspublishedonSeptember30,2010EffectsofFOXOGenotypesonLongevity:ABiodemographicAnalysisYiZeng,1,2,*LingguoCheng,2HuashuaiChen,3HuiqingCao,4ElizabethR.Hauser,5YuzhiLiu,2ZhenyuXia

3、o,2QihuaTan,6Xiao-LiTian,4,*andJamesW.Vaupel7,81CenterfortheStudyofAgingandHumanDevelopment,MedicalSchoolofDukeUniversity,Durham,NorthCarolina.2ChinaCenterforEconomicResearch,NationalSchoolofDevelopment,PekingUniversity,Beij

4、ing,China.3DepartmentofInternationalTrade,BusinessSchoolofXiangtanUniversity,Xiangtan,China.4DepartmentofHumanPopulationGenetics,InstituteofMolecularMedicine,PekingUniversity,Beijing,China.5CenterforHumanGenetics,MedicalSchoolof

5、DukeUniversity,Durham,NorthCarolina.6InstituteofPublicHealth,UniversityofSouthernDenmark,Odense,Denmark.Downloadedfrom7MaxPlanckInstituteforDemographicResearch,Rostock,Germany.8Population,PolicyandAgingResearchCenter,SanfordSchoo

6、lofPublicPolicy,DukeUniversity,Durham,NorthCarolina.*YiZengandXiaoLiTianshouldberegardedastheco-correspondingauthors.AddresscorrespondencetoYiZeng,PhD,CenterfortheStudyofAgingandHumanDevelopmentatMedicalSchoolofDukeUnive

7、rsityandChinaCenterforEconomicResearchatNationalSchoolofDevelopmentofPekingUniversity.Box3003,DukeUniversity,Durham,NC27710.Email:http://biomedgerontology.oxfordjournals.org/zengyi68@gmail.com.Basedondatafrom760centenariansand106

8、0middle-agecontrols(allHanChinese),thisarticlecontributesbiodemo-graphicinsightsandsynthesesconcerningthemagnitudeofeffectsoftheFOXOgenotypesonlongevity.We

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