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1、ReviewCircadianautophagyrhythm:alinkbetweenclockandmetabolism?1,21,21,21,2DiMa,SimingLi,MatthewM.MoluskyandJiandieD.Lin1LifeSciencesInstitute,UniversityofMichigan,210WashtenawAvenue,AnnArbor,MI48109,USA2DepartmentofCellandDevelopmentalBiology,UniversityofMichiganMedicalCenter,AnnA
2、rbor,MI48109,USANutrientandenergymetabolisminmammalsexhibitsaTranscriptionalprofilingrevealedthatalargenumberofstrongdiurnalrhythmthatalignswiththebodyclock.genesinvolvedinglucoseandlipidmetabolismaretempo-Circadianregulationofmetabolismismediatedthroughrallycontrolled[1216].Recent
3、chromatin-immunoprecip-reciprocalsignalingbetweentheclockandmetabolicitationsequencingstudiessupportthenotionthatmanyofregulatorynetworks.Recentworkhasdemonstratedtheserhythmicallyexpressedgenesaredirecttranscrip-thatautophagyisrhythmicallyactivatedinaclock-de-tionaltargetsofclock
4、genes,suchasBmal1andRev-erbapendentmanner.Becauseautophagyisaconserved[17,18].Clockexertsitsphysiologicaleffectsinpartbiologicalprocessthatcontributestonutrientandcell-throughthesedirecttranscriptionaltargets.Forexample,ularhomeostasis,itscyclicinductionmayprovideadiurnalregulatio
5、nofxenobioticdetoxificationismediatednovellinkbetweenclockandmetabolism.ThisreviewthroughthecircadianPAR-domainbasicleucinezipperdiscussesthemechanismsunderlyingcircadianauto-transcriptionfactorsDBP/TEF/HLF,allofwhichareclockphagyregulation,theroleofrhythmicautophagyintargets[6].He
6、paticlipogenesisandlipoproteinsecretionnutrientandenergymetabolism,anditsimplicationsarerhythmicallycontrolledbyseveralfactors,includinginphysiologyandmetabolicdisease.thetranscriptionfactorSREBP,smallheterodimerpart-ner(SHP),andthehistonedeacetylaseHDAC3[10,18,19].Nutrientandener
7、gymetabolismiscoupledtotimingNuclearhormonereceptors(NHRs)areafamilyofcuestranscriptionalregulatorsthatrespondtodiverseclassesNutrientandenergymetabolismistemporallyorganizedofmetabolitesandplayimportantrolesinmetabolicregu-inmammaliantissuestosynchronizethestorageandlation.Theexp
8、ressionofmanyNHRsexhibitscircadia
