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1、DOI:10.1093/jnci/djr360©TheAuthor(s)2011.PublishedbyOxfordUniversityPress.AdvanceAccesspublicationonOctober24,2011.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionNon-CommercialLicense(http://creativecommons.org/licenses/by-nc/3.0/),whichpermitsunrestrictednon-commerc
2、ialuse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.ARTICLETheRoleofPolymericImmunoglobulinReceptorinInflammation-InducedTumorMetastasisofHumanHepatocellularCarcinomaJingAi,QingjuanTang,YanlinWu,YangXu,TengFeng,RuiyuZhou,YiChen,XinGao,QingfengZhu,XihuaYue,QiumingPan
3、,SiyunXu,JingLi,MinHuang,JenniferDaugherty-Holtrop,YuanzhengHe,H.EricXu,JiaFan,JianDing,MeiyuGengManuscriptreceivedApril18,2011;revisedAugust16,2011;acceptedAugust17,2011.Correspondenceto:MeiyuGeng,PhDandJianDing,MD,PhD,DivisionofAnti-tumorPharmacology,StateKeyLaboratoryofDrugResearch,ShanghaiDownlo
4、adedfromInstituteofMateriaMedica,ChineseAcademyofSciences,555ZuchongzhiRd,Shanghai201203,People’sRepublicofChina(e-mail:mygeng@mail.shcnc.ac.cn;suozhang@mail.shcnc.ac.cn)andJiaFan,MD,DepartmentofLiverSurgery,LiverCancerInstitute,ZhongshanHospitalandShanghaiMedicalSchool,andInstituteofBiomedicalScien
5、ces,FudanUniversity,180FenglinRd,Shanghai200032,People’sRepublicofChina(e-mail:jiafan99@yahoo.com).http://jnci.oxfordjournals.org/BackgroundExpressionofthepolymericimmunoglobulinreceptor(pIgR),atransporterofpolymericIgAandIgM,iscom-monlyincreasedinresponsetoviralorbacterialinfections,linkinginnatean
6、dadaptiveimmunity.AbnormalexpressionofpIgRincancerwasalsoobserved,butitsclinicalrelevanceremainsuncertain.MethodsAhumanhepatocellularcarcinoma(HCC)tissuemicroarray(n=254)wasusedtoinvestigatetheassociationbetweenpIgRexpressionandearlyrecurrence.Anexperimentallungmetastasismodelusingseverecombinedimmu
7、ne-deficientmicewasappliedtodeterminethemetastaticpotentialofMadin–Darbycaninekidney(n=5micepergroup)andSMMC-7721(n=12micepergroup)cellsoverexpressingpIgRvscontrolcells.RNAinterference,immunoprecipita
