cyp2c19基因多态性指导下的个体化抗血小板治疗

《cyp2c19基因多态性指导下的个体化抗血小板治疗》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20122425HebeiMedicalUniversity硕士学位论文科学学位CYP2C19基因多态性指导下的个体化抗血小板治疗研究生：吴龙梅导师：李俊峡教授专业：内科学二级学院：白求恩国际和平医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第

2、一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名:导师签章:目录中文摘要··············································································

3、···1英文摘要·················································································4英文缩写·················································································8研究论文CYP2C19基因多态性指导下的个体化抗血小板治疗前言···········································

4、······································9材料与方法········································································9结果··············································································15附图·················································

5、·····························20附表··············································································23讨论··············································································30结论·····················································

6、·························35参考文献········································································36综述替格瑞洛在急性冠脉综合征中的临床应用···························42致谢····················································································50个人简历····

7、··········································································51中文摘要CYP2C19基因多态性指导下的个体化抗血小板治疗摘要目的：氯吡格雷抵抗（Clopidogrelresistance,CR）增加冠脉支架植入术后不良心血管事件的发生，而CR又与CYP2C19基因多态性有关，但是根据基因多态性及早调整经皮冠状动脉介入（Percutaneouscoronaryinterention，PCI）术后抗血小板治疗能

8、否降低心血管不良事件并不明确。本研究旨在探讨根据CYP2C19基因多态性个体化指导PCI术后抗血小板治疗对不良心血管事件的影响，从而为临床治疗提供更多的循证医学证据。方法：连续入选2013年4月至2014年1月因急性冠脉综合征（Acutecoronarysyndrome，ACS）就诊北京军区总医院并成功完成PCI手术的汉族患者338例，所有患者以1:2比例随机分入常规治疗组（Routinetreatmentgroup，RTG）和个体化治疗组（Individualizedtreatmentgrou