肝脏型脂肪酸结合蛋白介导脂肪酸通过内质网应激凋亡途径引起人近端小管上皮细胞凋亡

《肝脏型脂肪酸结合蛋白介导脂肪酸通过内质网应激凋亡途径引起人近端小管上皮细胞凋亡》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20122626HebeiMedicalUniversity硕士学位论文科学学位肝脏型脂肪酸结合蛋白介导脂肪酸通过内质网应激凋亡途径引起人近端小管上皮细胞凋亡研究生：张一鸣、导师：张连珊教授专业：病理学与病理生理学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，实验材料、

2、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担_靡;_摩管责任。研宄生签字‘%导师签章:级学院签章：l/)t年3月日河北医科大学研究生学位论文独创声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包括其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研宄生签字:导师签章:年3月訇曰目录中文摘要·················································································1英文摘要··

3、···············································································5英文缩写···············································································10研究论文肝脏型脂肪酸结合蛋白介导脂肪酸通过内质网应激凋亡途径引起人近端小管上皮细胞凋亡前言··········································································

4、······11材料与方法·······································································12结果················································································22附图················································································25讨论····························

5、····················································35结论················································································37参考文献··········································································38综述································································

6、·····················45致谢·····················································································57个人简历···············································································58中文摘要肝脏型脂肪酸结合蛋白介导脂肪酸通过内质网应激凋亡途径引起人近端小管上皮细胞凋亡摘要目的:蛋白尿是慢性肾脏疾病(Chronickidneydisease,CKD)的共同

7、表现，大量蛋白尿可引起肾小管及间质的损伤和炎症。而与白蛋白(albumin,Alb)结合的游离脂肪酸(freefatacids,FFAs)通过脂毒性，引起细胞功能障碍和损伤，参与了肾间质损伤的过程。已有研究表明饱和脂肪酸棕榈酸(Palmiticacids,PA)可诱导非脂肪细胞的损伤和凋亡。脂毒性包含了多种应激反应，如内质网应激和氧化应激等。内质网应激通过未折叠蛋白反应(unfoldedproteinresponse,UPR)维持细胞内环境的稳态。但持久强烈的ERS会通过内质网相关性死亡途径(ER-associateddeath)，引起细胞凋亡。肝脏型脂肪酸结合

8、蛋白(liver-typ