探究右美托咪定辅助椎管内麻醉的半数有效剂量

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1、授予单位代码—一10089学号或申请号20122564HebeiMedicalUniversity硕士学位论文科学学位探究右美托咪定辅助椎管内麻醉的半数有效剂量研究生：颜如玉导师：宋铁鹰教授专业：麻醉学二级学院：石家庄市第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位

2、河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。一r广.t，V广I«：V*./+'、•,-•、、-.J1研究生签名春r导师签章二级学院_肆盖章：Tt'•••”-*‘‘,•‘,^，.、>:乜年.3月过生r河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：i終导师签章年孑月

3、巧日目录中文摘要·············································································1英文摘要·············································································3英文缩写·············································································5研究论

4、文探究右美托咪定辅助椎管内麻醉的半数有效剂量前言·············································································6资料与方法····································································7结果···········································································

5、··11附图·············································································12附表·············································································13讨论·············································································13结论····

6、·········································································17参考文献·······································································17综述右美托咪定的临床研究及进展·········································20致谢·········································

7、··········································35个人简历·············································································36中文摘要探究右美托咪定辅助椎管内麻醉的半数有效剂量摘要目的：临床工作中遇到疾病患者常伴有不同程度的肥胖，很大部分原因其疾病是由肥胖本身所造成，因此需要手术治疗、实施麻醉的肥胖患者逐渐增多，然而肥胖已经改变了机体原有的正常生理机制，诸多部分如机体成分构成

8、发生改变，脂肪所占比例增多，相比之下骨骼肌肉，无机盐和水分的比例下调，对药物的代谢产生不同的影响，因此肥胖患者的药物代谢与正常体重患者的药物有所不同。采用序贯法评价体重指数（BMI）230~34kg/m的肥胖患者其肥胖因素对右美托咪定在骨科手术时行腰硬联合麻醉中半数有效剂量的影响。方法：选取2013年12月至2014年6月在石家庄市第一医院行择期下肢骨科手术病人28例，手术时间平均2h，年龄20~50岁，性别不限，ASA分级Ⅰ或Ⅱ级，分为2组，正常体重组