igf-1对脓毒症大鼠皮层保护及认知功能改善作用的研究

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1、分类号R651UDC616.8密级公开硕士学位论文IGF-1对脓毒症大鼠皮层保护及认知功能改善作用的研究杨阳培养类别全日制学位类型科学学位一级学科(专业类)临床医学二级学科(专业)外科学研究方向重症脑病指导教师李立宏副教授（副主任医师）培养单位唐都医院神经外科二〇一五年五月第四军医大学硕士学位论文目录缩略语表·································································································

2、·····························1中文摘要······························································································································2英文摘要·······················································································

3、·······································6前言·····························································································································11文献回顾···············································································

4、·············································13正文····························································································································24实验一脓毒症脑病大鼠皮层中IGF-1表达下降，细胞凋亡增加，IGF-1与抗凋亡作用密切相关································

5、·································································241.材料··························································································································242.方法·····················································

6、·····································································253.结果··························································································································304.讨论·················································

7、·········································································34实验二脓毒症大鼠存在认知功能受损和抑郁样情绪，而外源性IGF-1能够改善认知···················································································································361.材料··················

8、········································································································362.方法··························································································································373.