msc及polyic预刺激后对脓毒症大鼠肠屏障功能的保护作用及机制

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1、目录缩略语表1英文摘要2中文摘要5论文正文MSC及Poly(I：C)预刺激后对脓毒症大鼠肠屏障功能的保护作用及机制．．8第一章前言8第二章MSC及Poly(I：C)预刺激后对脓毒症大鼠肠屏障功能的保护作用及机制102．1材料和实验方法102．2实验结果212．3讨{仑．332．4小结．36全文结论．37参考文献38文献综述脓毒症肠功能损伤机制及防治研究进展．．43参考文献．50攻读学位期间的研究成果．56致{射．．57万方数据第三军医大学硕士学位论文缩略语表英文简称英文全称中文BSABovinealbumin牛血清白蛋

2、白CLPcecalligationandpuncture盲肠结扎穿孔DAdopamine多巴胺D．LacD．1acticacidD．乳酸DMEM／F12dulbecco’Smodifiedeaglemedium／改良的F12nutrientF．12ham’Smixture培养基DMEM／Highdulbecco’Smodifiedeaglemedium／改良的高糖Glucosehighglucose培养基EBEvansBlue伊文斯蓝FGFFibroblastgrowthfactor成纤维细胞生长因子GFPGreenf

3、luorescentprotein绿色荧光蛋白hhour小时ICUintensivecareunit重症监护室IL一10Interleukin．10白细胞介素．10LPSLipopolysaccharide脂多糖MAPmeanarterialbloodpressure平均动脉压MODSmultipleorgandysfunctionsyndrom多器官功能障碍MSCMesenchymalstemcell间充质干细胞Poly(I：C)Polyinosinic．polycytidylicacid聚肌苷酸胞苷酸SIRSSys

4、temicinflammatoryreponsesyndrome全身炎症反应综合症SDF．1aStromalcell．derivedfactor基质衍生因子TGF—ptransforminggrowthfactor转化生长因子TERtransepithelialelectricalresistance跨细胞电阻万方数据第三军医大学硕士学位论文ProtectiveeffectsofMSCandPoly(I：C)pretreatmentonintestinalbarrierfunctionandmechanisminsep

5、sisratsAbstractSepsisisacommonseverediseaseinintensivecareunit，itsincidenceandmortalityratesarestillhigll。Studiesshowedthatthereare21millionpopulationinfectioninducedsepsisgloballyeveryyear．Theintestinalbarrierdysfunctionusuallyoccurredinearlysepsis，itcandirectl

6、ycausetheincreaseofintestinalpermeabilityandleadstothetranslocationofbacteriafromtheintestineintotheblood，whichcanaggravatesepsisandcausethemultipleorgandysfunctionsyndromes(MODS)．Therefore，protectingtheintestinalbarrierfunctioninsepsisisimportant．Mesenchymalste

7、mcells(MSC)，akindofpluripotentstemcells，candifferentiateintoepithelialcells，adipocytes，osteoblasts，andsecreteavarietyofnutritionchemokinestorepairtissuedamage．StudiesdemonstratedthatMSCcouldimprovethesurvivalratesinsepsisrats．Inaddition，MSChasbeneficialeffectfor

8、intestinalbarrierinmanykindsofgutdiseaseslikeinflammatoryboweldisease，radioactiveintestinalinjury,ischemiareperfusioninjuryandSOon．WhilewhetherMSChasprotectiveeffecto