血必净注射液对脓毒症患者细胞因子和凝血功能的影响

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1、授予单位代码10089学号或申请号HebeiMedicalUniversity硕士学位论文科学学位血必净注射液对脓毒症患者细胞因子和凝血功能的影响作者姓名：高平导师：苏素文教授专业：药理学二级学院：河北医科大学2015年10月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师，由本人独立完成。Ｃ或指导小组）的指导下本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文一，第署名为单位河北医科大学，

2、试验材輯、原始数据、申报的专巧等知识产权均归河北医科大学巧有。否则。，承担相应法律责任研究生签名导师签章二级学院领导盖章年月曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果。，指导教师对此进行了审定本论文由本人独立撰写，文责自负。研究生签名：导师签章：爲孚冻Ｉ义年月曰目录中文摘要·········································

3、·····································1英文摘要··············································································3研究论文血必净注射液对脓毒症患者细胞因子和凝血功能的影响前言··············································································5材料与方法····························

4、·········································6结果··············································································8附表··············································································11讨论························································

5、······················15结论··············································································17参考文献········································································17综述脓毒症的发病机制及其治疗进展········································21致谢···················

6、·································································27个人简历··············································································28中文摘要血必净注射液对脓毒症患者细胞因子和凝血功能的影响摘要目的：探讨脓毒症患者应用血必净注射液的治疗效果及对细胞因子和凝血功能的影响。方法：选取脓毒症患者60例，均为我院2014年2月至2015年2月收治，依据入院顺序分组

7、，就常规标准治疗(对照组，n=30)与常规标准治疗加用血必净治疗(观察组，n=30)效果展开对比。结果：治疗前和治疗后1d两组患者血浆中各项指标、APACHEII评分和Marshall评分均未见明显差别。治疗后第3天，两组患者血浆中TNF-α＋及IL-6水平均较治疗前下降(P<0.05或0.01)，观察组尚伴有CD3T和NK水平的升高(P<0.05或0.01)，且观察组血浆中TNF-α水平明显低于对照组(P<0.01)，而NK水平明显高于对照组(P<0.01)。治疗后第7d,两组患者血清中除TNF-α和IL-6水平仍持续

8、性降低(P均<0.01)外，血浆中CD3＋＋＋T、CD4T、CD8T、和NK水平均升高((P<0.05或0.01)。观察组血浆＋中TNF-α水平明显低于对照组(P<0.01)，而CD3T水平及NK水平明显高于对照组(P<0.01)。治疗后第10d，两组患者血清中TNF-α和IL-6水＋＋＋平显著降低(P均<0.01)