沧州地区妊娠期妇女甲状腺功能参考值研究

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1、授予单位代码10089学号或申请号13S05对妗(E钭大？HebeiMedicalUniversity硕士学位论文在职科学学位沧州地区妊娠期妇女甲状腺功能参考值研究学位申请人：魏粤晓导师：辛虹教授专业：妇产科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科

2、大学所有。否则,承担相应法律责任。、27v研究生签名导师签章级学院领导盖章；1年r月<日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。’研究生签名：親秘导师签章年月水日目录中文摘要·············································································1英文摘要··························

3、···················································3英文缩写·············································································6研究论文沧州地区妊娠期妇女甲状腺功能参考值研究前言·············································································7材料与方法············································

4、························8结果·············································································9附图·············································································13附表·············································································16讨论·················

5、····························································20结论·············································································26参考文献·······································································26综述妊娠期妇女甲状腺功能检测进展······································33致谢········

6、···········································································45个人简历·············································································46中文摘要沧州地区妊娠期妇女甲状腺功能参考值研究摘要目的：甲状腺功能异常是妊娠期妇女常见的内科疾病之一，可导致不良妊娠结局。妊娠合并甲状腺疾病已越来越受到人们的重视。2011年美国甲状腺协会（Americanthyroidassociation，ATA）

7、颁布了《妊娠和产后甲状腺疾病诊治指南》，建议各地区建立自己的妊娠期甲状腺参考值范围。2012年中华医学会内分泌分会和围产医学分会颁布了《妊娠和产后甲状腺疾病诊治指南》（简称指南），并根据不同的检验试剂和方法，给出了不同的推荐参考值，沧州地区作为北方沿海城市，地处环渤海中心地带，为碘充足、高氟地区，而《指南》推荐的参考值范围的研究人群多为南方沿海或北方内陆城市，其甲状腺激素指标应存在差异，本研究旨在建立沧州地区妊娠期妇女孕早期（T1期，≤12周）、孕中期（T2期，13周-28周）、孕晚期（T3期，＞28周）特异性血清TSH、FT3、FT4参考值范围；分析TPOAb