叶酸靶向丹参酮ⅱ_a白蛋白纳米粒的制备及其抗肿瘤活性研究

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1、单位代码；１０１６０分类号民２８４．２２２０１３７学号：２０１？系窗《挺硕击学位论文＊Ｉ■题目：叶酸祀向丹参丽ｎＡ白蛋白纳米粒的制备及其抗肿瘤活性研究一．．ｆ’心．ｒ：ｓｔｕｄｙｏｎｔｈｅｐｒｅｐａｒａｔｉｏｎａｎｄｔｈｅ－－ｙ：ａｎｔｉｔｕｍｏ「ａｃｔｉｖｉｔｙｏｆｆｏｌａｔｅｔａｒｇｅｔｅｄ：．遞；Ｔａｎ－ＩＩｌｏａｄｅｄＢＳＡｎａｎｏａｒｔｉｃｌｅｓ藝Ａｐ＇４研究生：刘丽薇导师：承伟学科专业；生药学＇〇４－一２０论文课题起止时间

2、：２０１３年１１月１５年３月论文完成时间：２０１５年３月？－Ｖ馨辽宁医学院研究生学位论文独创性声明本人申明所呈交的学位论文畏我本人在导师指导下进行的研究＾工作及取得的研究成果。据我所知１，除了文中持别加乂标注和致谢的地方外，论文中不包含其他人色经发表或撰写过的研究成果，也不包一含为获得我校或其他教育机构的学位或证书而使用过的材料，与我同工作的同志对本研究所做的任何贡献均臣在论文中作了明确的说明并表示谢意。一申请学位论文与资料若有不实之处，本人承担切相关责任。论文作者签《：对爾菊ｆｔ日期：＞Ｔ）／ｒｒ．Ａｄ

3、ｉｌ宁医学院研究生学位论文版权使用授权书：本人完全了解迂宁医学院有关保护知识产权的规定，印研究生在攻读学位期间论文工作的知巧产权单位属迂宁医学院。本人保证毕业离校后，发表论文或使用论文工作成果时署省单位为辽宁医学晓，岛导师为通讯作者，通讯作者单位亦署名為巧宁医学院。学校有权保留并向国家有关部口或机拘送交论文的复印件和磁盘，允许论文被查＾阅和借阅。学校可１义公布学位论文的全部或部分内容（保密巧容除、外），政采用影巧缩印或其他手段保存论文。论文作者签名：如帝據＿指导教师签名：－课專—．－目录一、摘要中文论著摘要········

4、······································································1英文论著摘要··············································································3二、英文缩略语表·············································································5三、论文·······································

5、··················································6前言·······················································································6第一章丹参酮ⅡA白蛋白纳米粒的制备及优化·····································9实验材料与方法······································································9结果······

6、··········································································11讨论················································································16结论················································································16第二章偶联叶酸丹参酮ⅡA白蛋白纳米粒的制备及表征·················

7、······17实验材料与方法····································································17结果················································································18讨论················································································19结论······························

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